Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study

doi:10.3390/ijerph17124581

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24803

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24803

Title:	Risk Factors in and Long-Term Survival of Patients with Post-Transplantation Diabetes Mellitus: A Retrospective Cohort Study
Authors:	Cheng, CY;Chen, CH;Wu, MF;Wu, MJ;Chen, JP;Liu, YM;Hou, YC;Wang, HY
Keywords:	immunosuppressant;post-transplant diabetes mellitus;risk factor;survival rate
Date:	2020
Issue Date:	2022-08-09T08:08:15Z (UTC)
Publisher:	MDPI
Abstract:	Post-transplant diabetes mellitus (PTDM) is associated with infection, cardiovascular morbidity, and mortality. A retrospective cohort study involving patients who underwent renal transplantation in a transplantation center in Taiwan from January 2000 to December 2018 was conducted to investigate the incidence and risk factors of PTDM and long-term patient and graft survival rates. High age (45-65 vs. <45 years, adjusted odds ratio (aOR) = 2.90, 95% confidence interval (CI) = 1.64-5.13,p< 0.001), high body mass index (>27 vs. <24 kg/m(2), aOR = 5.35, 95% CI = 2.75-10.42,p< 0.001), and deceased organ donor (cadaveric vs. living, aOR = 2.01, 95% CI = 1.03-3.93,p= 0.04) were the three most important risk factors for the development of PTDM. The cumulative survival rate of patients and allografts was higher in patients without PTDM than in those with PTDM(p= 0.007 and 0.041, respectively). Concurrent use of calcineurin inhibitors and mammalian target of rapamycin inhibitors (mTORis) decreased the risk of PTDM (tacrolimus vs. tacrolimus with mTORi, aOR = 0.28, 95% CI = 0.14-0.55,p< 0.001). Investigating PTDM risk factors before and modifying immunosuppressant regimens after transplantation may effectively prevent PTDM development.
URI:	http://dx.doi.org/10.3390/ijerph17124581 https://www.webofscience.com/wos/woscc/full-record/WOS:000554686100001 https://ir.csmu.edu.tw:8080/handle/310902500/24803
Relation:	INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH ,2020 ,v17 ,issue 12
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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