Patients With Rheumatoid Arthritis Increased Risk of Developing Osteoarthritis: A Nationwide Population-Based Cohort Study in Taiwan

doi:10.3389/fmed.2020.00392

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24799

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24799

Title:	Patients With Rheumatoid Arthritis Increased Risk of Developing Osteoarthritis: A Nationwide Population-Based Cohort Study in Taiwan
Authors:	Lee, YH;Tsou, HK;Kao, SL;Gau, SY;Bai, YC;Lin, MC;Wei, JCC
Keywords:	rheumatoid arthritis;osteoarthritis;population-based cohort study;autoimmue disease;chronic inflammation
Date:	2020
Issue Date:	2022-08-09T08:08:11Z (UTC)
Publisher:	FRONTIERS MEDIA SA
Abstract:	Objective:To investigate the risk of developing OA in patients diagnosed with RA. Methods:In this study, we presented gender, age, urbanization, occupation and, comorbidities in a RA cohort and a non-RA cohort based on number and percentage. We investigated the OA risk in patients with RA. We conducted a retrospective cohort study with a 13-year longitudinal follow-up in Taiwan. Patients who received RA diagnoses between 2000 and 2012 were enrolled in the study cohort. The non-RA cohort were 1:1 propensity score matched with the RA cohort by age, gender, index year, urbanization, occupation, and comorbidities. The hazard ratios (HRs) and adjusted HRs (aHRs) were estimated after confounders were adjusted. Sensitivity analysis utilizing the Longitudinal Health Insurance Database (LHID) was conducted. Results:We totally enrolled 63,626 cases in RA patients (study cohort) and matched controls. In the RA cohort, the crude HR for OA was 2.86 (95% confidence interval (CI), 2.63-3.11,p< 0.001), and the aHR was 2.75 (95% CI, 2.52-2.99,p< 0.001). (The study demonstrated that patients with RA had a higher risk for developing OA compared with the non-RA controls. Conclusion:Developing effective OA prevention strategies are necessary in patients with RA. This finding may be extended to evaluate the risk of OA among other kinds of inflammatory autoimmune diseases. Identifying the key pathogenesis mechanisms are necessary in the future study.
URI:	http://dx.doi.org/10.3389/fmed.2020.00392 https://www.webofscience.com/wos/woscc/full-record/WOS:000574598000001 https://ir.csmu.edu.tw:8080/handle/310902500/24799
Relation:	FRONTIERS IN MEDICINE ,2020 ,v7
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	254	View/Open

Loading...