Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway

doi:10.3389/fendo.2020.568436

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24795

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24795

Title:	Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway
Authors:	Kumar, VB;Lin, SH;Mahalakshmi, B;Lo, YS;Lin, CC;Chuang, YC;Hsieh, MJ;Chen, MK
Keywords:	sodium danshensu (Pubchem CID;23711819);oral squamous cell carcinoma (OSCC);P38 signaling pathway;migration;invasion
Date:	2020
Issue Date:	2022-08-09T08:08:07Z (UTC)
Publisher:	FRONTIERS MEDIA SA
ISSN:	1664-2392
Abstract:	Background:Oral squamous cell carcinoma (OSCC) that comprises about 90% of all oral cancer cases is associated with poor prognosis due to its highly metastatic nature. The majority of OSCC treatment options are related detrimental side-effects. Hypothesis/Purpose:The present study aimed at deciphering the effects of a bioactive phytochemical, sodium danshensu, on human oral cancer cell metastasis. Methods and Results:The treatment of FaDu and Ca9-22 cells with different doses of sodium danshensu (25, 50, and 100 mu M) caused a significant reduction in cellular motility, migration, and invasion, as compared to the untreated cells. This effect was associated with a reduced expression of MMP-2, vimentin and N-cadherin, together with an enhanced expression of E-cadherin and ZO-1. Further investigation on the molecular mechanism revealed that treatment with sodium danshensu caused significant reduction in p38 phosphorylation; however, phosphorylation of ERK1/2 significantly decreased only in FaDu cells, whereas p-JNK1/2 did not show any alteration. A combination of p38 and JNK1/2 inhibitors with sodium danshensu also reduced the migration in the FaDu and Ca9-22 cell lines. Conclusion:Collectively, the present study findings reveal that sodium danshensu execute anti-metastatic effect by suppressing p38 phosphorylation in human oral cancer. The study identifies sodium danshensu as a potential natural anticancer agent that can be used therapeutically to manage highly metastatic OSCC.
URI:	http://dx.doi.org/10.3389/fendo.2020.568436 https://www.webofscience.com/wos/woscc/full-record/WOS:000579399900001 https://ir.csmu.edu.tw:8080/handle/310902500/24795
Relation:	FRONTIERS IN ENDOCRINOLOGY ,2020 ,v11
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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