中山醫學大學機構典藏 CSMUIR:Item 310902500/24788
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    請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24788


    題名: Low Concentrations of Dehydroepiandrosterone Sulfate are Associated with Depression and Fatigue in Patients with Non-Small-Cell Lung Cancer After Chemotherapy
    作者: Fang, YH;Hsieh, MJ;Hung, MS;Lin, YC;Kuo, LT;Lu, ML;Tzang, BS;Chen, VCH
    關鍵詞: cancer-related fatigue;chemotherapy;DHEA;DHEAS;lung cancer
    日期: 2020
    上傳時間: 2022-08-09T08:08:00Z (UTC)
    出版者: DOVE MEDICAL PRESS LTD
    摘要: Background: Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) concentrations were reported to decrease in patients with advanced cancer. However, the clinical significance of DHEA and DHEAS concentrations in patients with NSCLC receiving chemotherapy (CT) has not been sufficiently documented. Objective: To evaluate the correlation between mental health and hormone concentrations on patients with advanced non-small-cell lung cancer (NSCLC). Materials and Methods: The present study was a cross-sectional analysis based on a self-reported psychological investigation. Salivary samples were collected from 22 patients with advanced NSCLC after CT and 17 healthy controls. The concentrations of DHEA, DHEAS, and cortisol were analyzed to investigate their associations with the results of self-reported questionnaires on psychological health. Results: Patients with advanced NSCLC exhibited significantly higher Patient Health Questionnaire (PHQ-9) and Startle, Physiological arousal, Anger, and Numbness-Chinese version (SPAN-C) scores, poorer health conditions, lower sleep quality, and more severe fatigue after CT than did healthy controls, and salivary concentrations of DHEA and DHEAS were significantly lower among patients after CT than among controls. DHEAS concentrations were negatively associated with depression scores (PHQ-9, r = -0.496, P = 0.019) and fatigue scores (Brief Fatigue Inventory-Taiwan, r = -0.562, P = 0.006). Conclusion: Patients with advanced NSCLC after CT had lower DHEA and DHEAS concentrations than did controls. Lower DHEAS concentrations were associated with higher fatigue and depression scores.
    URI: http://dx.doi.org/10.2147/NDT.S265182
    https://www.webofscience.com/wos/woscc/full-record/WOS:000573658300001
    https://ir.csmu.edu.tw:8080/handle/310902500/24788
    關聯: NEUROPSYCHIATRIC DISEASE AND TREATMENT ,2020 ,v16 ,p2103-2109
    顯示於類別:[中山醫學大學研究成果] 期刊論文

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