Low Concentrations of Dehydroepiandrosterone Sulfate are Associated with Depression and Fatigue in Patients with Non-Small-Cell Lung Cancer After Chemotherapy

doi:10.2147/NDT.S265182

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24788

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题名:	Low Concentrations of Dehydroepiandrosterone Sulfate are Associated with Depression and Fatigue in Patients with Non-Small-Cell Lung Cancer After Chemotherapy
作者:	Fang, YH;Hsieh, MJ;Hung, MS;Lin, YC;Kuo, LT;Lu, ML;Tzang, BS;Chen, VCH
关键词:	cancer-related fatigue;chemotherapy;DHEA;DHEAS;lung cancer
日期:	2020
上传时间:	2022-08-09T08:08:00Z (UTC)
出版者:	DOVE MEDICAL PRESS LTD
摘要:	Background: Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) concentrations were reported to decrease in patients with advanced cancer. However, the clinical significance of DHEA and DHEAS concentrations in patients with NSCLC receiving chemotherapy (CT) has not been sufficiently documented. Objective: To evaluate the correlation between mental health and hormone concentrations on patients with advanced non-small-cell lung cancer (NSCLC). Materials and Methods: The present study was a cross-sectional analysis based on a self-reported psychological investigation. Salivary samples were collected from 22 patients with advanced NSCLC after CT and 17 healthy controls. The concentrations of DHEA, DHEAS, and cortisol were analyzed to investigate their associations with the results of self-reported questionnaires on psychological health. Results: Patients with advanced NSCLC exhibited significantly higher Patient Health Questionnaire (PHQ-9) and Startle, Physiological arousal, Anger, and Numbness-Chinese version (SPAN-C) scores, poorer health conditions, lower sleep quality, and more severe fatigue after CT than did healthy controls, and salivary concentrations of DHEA and DHEAS were significantly lower among patients after CT than among controls. DHEAS concentrations were negatively associated with depression scores (PHQ-9, r = -0.496, P = 0.019) and fatigue scores (Brief Fatigue Inventory-Taiwan, r = -0.562, P = 0.006). Conclusion: Patients with advanced NSCLC after CT had lower DHEA and DHEAS concentrations than did controls. Lower DHEAS concentrations were associated with higher fatigue and depression scores.
URI:	http://dx.doi.org/10.2147/NDT.S265182 https://www.webofscience.com/wos/woscc/full-record/WOS:000573658300001 https://ir.csmu.edu.tw:8080/handle/310902500/24788
關聯:	NEUROPSYCHIATRIC DISEASE AND TREATMENT ,2020 ,v16 ,p2103-2109
显示于类别:	[中山醫學大學研究成果] 期刊論文

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