中山醫學大學機構典藏 CSMUIR:Item 310902500/24764
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    题名: Vagus nerve stimulation in pediatric patients with failed epilepsy surgery
    作者: Tsai, JD;Fan, PC;Lee, WT;Hung, PL;Hung, KL;Wang, HS;Lin, KL
    关键词: Refractory epilepsy;Epilepsy surgery;Vagus nerve stimulation;Seizures frequency reduction
    日期: 2021
    上传时间: 2022-08-09T08:07:38Z (UTC)
    出版者: SPRINGER HEIDELBERG
    ISSN: 0300-9009
    摘要: Adequate control of pharmacoresistant epilepsy continues to be a challenge. Multiple studies have reported the benefits of epilepsy surgery and vagus nerve stimulation for children with pharmacoresistant epilepsy. Little is known about the role of vagus nerve stimulation for children with failed epilepsy surgeries. The aim of this study was to examine the effects of vagus nerve stimulation on seizure frequency reduction for children with failed epilepsy surgeries. We retrospectively reviewed 85 children with pharmacoresistant epilepsy who underwent vagus nerve stimulation. Six of these patients underwent epilepsy surgery before vagus nerve stimulation (group I) and 79 patients received only vagus nerve stimulation (group II). We recorded seizure frequency at 3, 12, 24 and 36 months after vagus nerve stimulator implantation. Both groups had reduced seizure frequencies at the 3-, 12-, 24- and 36-month follow-up (p = 0.044 for group I trends and 0.008 for group II trends). Vagus nerve stimulator implantations significantly improve seizure frequency for children with or without previous epilepsy surgery at 3, 12, 24 and 36 months. These findings suggest that vagus nerve stimulation should be considered an alternative therapy for pediatric patients with previous failed surgeries.
    URI: http://dx.doi.org/10.1007/s13760-020-01303-8
    https://www.webofscience.com/wos/woscc/full-record/WOS:000561306600002
    https://ir.csmu.edu.tw:8080/handle/310902500/24764
    關聯: ACTA NEUROLOGICA BELGICA ,2021 ,v121 ,issue 5 ,p1305-1309
    显示于类别:[中山醫學大學研究成果] 期刊論文

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