Association between EGFR Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer

doi:10.3390/diagnostics10090692

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24747

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题名:	Association between EGFR Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer
作者:	Lin, CH;Yang, PJ;Lin, SH;Yeh, KT;Tsao, TCY;Chen, YE;Lin, SH;Yang, SF
关键词:	adenocarcinoma;EGFRmutation;antioxidant gene polymorphisms
日期:	2020
上传时间:	2022-08-09T08:07:22Z (UTC)
出版者:	MDPI
摘要:	EGFRmutation status is considered as an important predictor of therapeutic responsiveness in non-small-cell lung carcinoma patients. Recent evidence suggests that antioxidant gene polymorphisms are potential predictors of lung cancer risk. Thus, stratification ofEGFRmutation-related phenotypes by antioxidant gene polymorphism status can be an effective approach in terms of improving the prognosis of lung cancer patients. The present study was designed to evaluate the distribution frequency of antioxidant gene polymorphisms in lung adenocarcinoma, as well as its association with hotspot EGFR mutations. The study findings revealed that a statistically significant association exists between EGFRL858R mutation and AG + GG genotypes of SODrs4880 polymorphism. Furthermore, the subgroup analysis data revealed that compared to AA genotype of SODrs4880, AG + GG genotypes were significantly associated with advanced cancer stage and distant metastasis. Taken together, these findings can be utilized clinically to predict cancer aggressiveness, metastatic, potential and therapeutic responsiveness of lung cancer patients.
URI:	http://dx.doi.org/10.3390/diagnostics10090692 https://www.webofscience.com/wos/woscc/full-record/WOS:000579937200001 https://ir.csmu.edu.tw:8080/handle/310902500/24747
關聯:	DIAGNOSTICS ,2020 ,v10 ,issue 9
显示于类别:	[中山醫學大學研究成果] 期刊論文

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