中山醫學大學機構典藏 CSMUIR:Item 310902500/24736
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    題名: The impact of rehabilitation frequency on the risk of stroke in patients with rheumatoid arthritis
    作者: Cheng, YY;Chang, ST;Kao, CL;Chen, YH;Lin, CH
    日期: 2020
    上傳時間: 2022-08-09T08:07:11Z (UTC)
    出版者: PUBLIC LIBRARY SCIENCE
    ISSN: 1932-6203
    摘要: Background Patients with rheumatoid arthritis are at higher risk of developing stroke due to augmented systemic inflammation. While regular exercise has been shown to reduce inflammation in human subjects, the purpose of our study is to determine whether increased frequency of rehabilitation is protective against stroke or not. Methods A total of 16,224 rheumatoid arthritis patients with a catastrophic illness certificate were identified in our database from 2000 to 2006, and 663 of them developed stroke before the end of 2013. After statistically matching for age, sex, and the time interval between the diagnosis of rheumatoid arthritis and stroke, 642 patients without stroke were identified as the control group. Analyses with Student's t test and Chi-square test were done to compare the clinical characteristics of patients with and without stroke, and logistic regression analysis was then performed to evaluate the odds ratio of stroke. Results Higher odds ratio of stroke was revealed in patients with hypertension, diabetes mellitus, and moderate degree of rheumatoid arthritis disease severity. Furthermore, more than 40 rehabilitation sessions per year reduced the risk of developing stroke in patients with moderate disease severity. Conclusions Physical activities brought by more rehabilitation sessions are beneficial and should be encouraged in patients with rheumatoid arthritis, particularly for those with higher disease activity but not taking biologic agents.
    URI: http://dx.doi.org/10.1371/journal.pone.0227514
    https://www.webofscience.com/wos/woscc/full-record/WOS:000508185400001
    https://ir.csmu.edu.tw:8080/handle/310902500/24736
    關聯: PLOS ONE ,2020 ,v15 ,issue 1
    顯示於類別:[中山醫學大學研究成果] 期刊論文

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