The impact of rehabilitation frequency on the risk of stroke in patients with rheumatoid arthritis

doi:10.1371/journal.pone.0227514

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24736

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24736

Title:	The impact of rehabilitation frequency on the risk of stroke in patients with rheumatoid arthritis
Authors:	Cheng, YY;Chang, ST;Kao, CL;Chen, YH;Lin, CH
Date:	2020
Issue Date:	2022-08-09T08:07:11Z (UTC)
Publisher:	PUBLIC LIBRARY SCIENCE
ISSN:	1932-6203
Abstract:	Background Patients with rheumatoid arthritis are at higher risk of developing stroke due to augmented systemic inflammation. While regular exercise has been shown to reduce inflammation in human subjects, the purpose of our study is to determine whether increased frequency of rehabilitation is protective against stroke or not. Methods A total of 16,224 rheumatoid arthritis patients with a catastrophic illness certificate were identified in our database from 2000 to 2006, and 663 of them developed stroke before the end of 2013. After statistically matching for age, sex, and the time interval between the diagnosis of rheumatoid arthritis and stroke, 642 patients without stroke were identified as the control group. Analyses with Student's t test and Chi-square test were done to compare the clinical characteristics of patients with and without stroke, and logistic regression analysis was then performed to evaluate the odds ratio of stroke. Results Higher odds ratio of stroke was revealed in patients with hypertension, diabetes mellitus, and moderate degree of rheumatoid arthritis disease severity. Furthermore, more than 40 rehabilitation sessions per year reduced the risk of developing stroke in patients with moderate disease severity. Conclusions Physical activities brought by more rehabilitation sessions are beneficial and should be encouraged in patients with rheumatoid arthritis, particularly for those with higher disease activity but not taking biologic agents.
URI:	http://dx.doi.org/10.1371/journal.pone.0227514 https://www.webofscience.com/wos/woscc/full-record/WOS:000508185400001 https://ir.csmu.edu.tw:8080/handle/310902500/24736
Relation:	PLOS ONE ,2020 ,v15 ,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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