RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese

doi:10.1097/JCMA.0000000000000250

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24733

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24733

Title:	RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese
Authors:	Hsu, LC;Hsu, LS;Lee, TH
Keywords:	Genetic;Polymorphism;RGS5;Stroke
Date:	2020
Issue Date:	2022-08-09T08:07:08Z (UTC)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
ISSN:	1726-4901
Abstract:	Background: The regulator of G-protein signaling protein 5 (RGS5) has been demonstrated to play a role in regulating blood pressure and cardiovascular function. Studies have shown that RGS5 polymorphisms exhibit susceptibility to hypertension. However, no study has yet been performed among stroke patients. Methods: To evaluate whether RGS5 rs4657251 is a susceptibility gene for stroke, we performed a case-control association study involving 714 large-artery atherosclerosis (LAA) patients, 383 small vessel occlusion (SVO) patients, 401 hypertensive intracranial hemorrhages (HICH), and 626 controls. The RGS5 rs4657251 polymorphism was analyzed through polymerase chain reaction. Results: The TC genotype was significantly higher in the SVO group compared with that in the control group (odds ratio [OR] = 1.34, 95% confidence interval [CI] = 1.02-1.76, p = 0.035). In addition, the dominant phenotype (TC + CC vs TT) was also significantly different between the SVO and the control groups (OR = 1.31, 95% CI = 1.01-1.70, p = 0.046). However, no association was found between RGS5 rs4657251 and LAA an HICH. After adjustment with gender, diabetes, smoking, cholesterol and low-density lipoprotein levels, RGS5 rs4657251 polymorphism remained an independent risk factor for SVO (OR = 1.49; 95% CI = 1.12-1.98) but not for LAA or HICH. Conclusion: Our findings, obtained among Taiwan Han Chinese subjects, provide the first evidence that RGS5 rs4657251 polymorphism is an independent risk factor for SVO.
URI:	http://dx.doi.org/10.1097/JCMA.0000000000000250 https://www.webofscience.com/wos/woscc/full-record/WOS:000524756800009 https://ir.csmu.edu.tw:8080/handle/310902500/24733
Relation:	JOURNAL OF THE CHINESE MEDICAL ASSOCIATION ,2020 ,v83 ,issue 3 ,p251-254
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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