Limited Knee-Joint Range of Motion in Patients With Tophaceous Gout Improved With Medical Treatment: A 18-Months Follow Up

doi:10.3389/fmed.2020.00074

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24726

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24726

Title:	Limited Knee-Joint Range of Motion in Patients With Tophaceous Gout Improved With Medical Treatment: A 18-Months Follow Up
Authors:	Lu, CC;Wei, JCC;Chang, CA;Chen, CM;Tsai, SW;Yeh, CJ
Keywords:	gout;tophi;intra-articular;magnetic resonance imaging;urate-lowering therapy
Date:	2020
Issue Date:	2022-08-09T08:07:01Z (UTC)
Publisher:	FRONTIERS MEDIA SA
Abstract:	Objectives: Tophi may occur within the knee joint causing limited knee-joint range of motion (knee motion). We investigated the relationships between knee motion, total intra-articular tophi size (tIA-tophi), and total subcutaneous tophi size (tSC-tophi) and determined knee motion improvement after continual urate-lowering therapy (ULT). Methods: A total of 26 patients with tophaceous gout and limited knee motion were enrolled. Inclusion criteria were age <= 60 years and preserved knee joint space on a plain radiograph. tSC-tophi were measured using a Vernier caliper and tIA-tophi were measured using magnetic resonance imaging software. All patients were re-evaluated after 12-24 months of continual ULT. Upon initial visit, knee motion was related to tIA-tophi and tSC-tophi. Results: After an average of 18.2 months of ULT, the reduction in tSC-tophi was correlated with the reduction in tIA-tophi (P = 0.014, r = 0.395) and improvement in knee motion (P = 0.038, r = 0.408). Knee motion can be eventually improved even in cases of poor initial knee motion (P = 0.000, r = -0.911) or large initial tIA-tophi (P = 0.014, r = 0.476). Tophi can occur in any location within the knee joint. In multiple lineal regression, knee motion was predicted to improve 8.39 degrees for every 10cm of tIA-tophi reduction. Conclusions: Limited knee motion in patients with intra-articular tophi improved with medical treatment, regardless of initial severity. Furthermore, tSC-tophi can be used as an indicator of limited knee motion and their improvement as a predictor of knee motion improvement.
URI:	http://dx.doi.org/10.3389/fmed.2020.00074 https://www.webofscience.com/wos/woscc/full-record/WOS:000525016700001 https://ir.csmu.edu.tw:8080/handle/310902500/24726
Relation:	FRONTIERS IN MEDICINE ,2020 ,v7
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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