中山醫學大學機構典藏 CSMUIR:Item 310902500/24713
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    题名: Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK-mediated signaling pathway
    作者: Hsieh, YH;Syu, RJ;Lee, CC;Lin, SH;Lee, CH;Cheng, CW;Tsai, JP
    关键词: arecoline;chronic kidney disease;epithelial mesenchymal transition;ERK
    日期: 2020
    上传时间: 2022-08-09T08:06:49Z (UTC)
    出版者: WILEY
    ISSN: 1520-4081
    摘要: Arecoline, a component of betel nuts, is a known carcinogen that causes oral cancers among those who chew betel nuts. Betel nut chewing is also associated with an increased risk of chronic kidney disease (CKD), but the role of arecoline in this association is unclear. This in vitro study investigates the effects of arecoline on cultured human kidney (HK2) cells. We observed that arecoline had no effect on cell viability but increased cell migration in a dose-dependent manner. Western blot analysis showed that arecoline treatment caused a dose-dependent decrease in E-cadherin expression and dose-dependent increases in N-cadherin, vimentin, alpha-SMA, and collagen expression; reverse transcriptase-polymerase chain reaction analysis revealed dose-dependent increases in alpha-SMA and collagen mRNA. Arecoline treatment upregulated the expression of phosphorylated extracellular signal-regulated kinase through epithelial mesenchymal transition and renal fibrosis in HK2 cells. These findings demonstrate that arecoline plays a role in inducing the epithelial mesenchymal transition and fibrogenesis in renal tubule cells and suggest that arecoline promotes the progression of CKD.
    URI: http://dx.doi.org/10.1002/tox.22937
    https://www.webofscience.com/wos/woscc/full-record/WOS:000534652600001
    https://ir.csmu.edu.tw:8080/handle/310902500/24713
    關聯: ENVIRONMENTAL TOXICOLOGY ,2020 ,v35 ,issue 9 ,p1007-1014
    显示于类别:[中山醫學大學研究成果] 期刊論文

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