Clinical treatment and medication in decreasing the development of major depression caused by spinal fracture

doi:10.1177/0300060520972885

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24673

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24673

Title:	Clinical treatment and medication in decreasing the development of major depression caused by spinal fracture
Authors:	Chang, CY;Chen, WL;Hsieh, PY;Ho, SY;Huang, CC;Lee, TH;Chou, CC;Chang, CF;Law, YY;Lin, YR
Keywords:	Spinal fracture;depression;surgical intervention;narcotics;chronic pain;activities of daily living
Date:	2020
Issue Date:	2022-08-09T08:06:09Z (UTC)
Publisher:	SAGE PUBLICATIONS LTD
ISSN:	0300-0605
Abstract:	Background Chronic pain and limited activities of daily living after spinal fracture may induce the occurrence of major depression (MD); however, risk factors regarding medications, surgical intervention, and severity of fracture are unclear. We aimed to analyze risk factors of MD development after spinal fracture. Methods This was a retrospective database study, using the health care database of the Taiwan government. We included 11,225 patients with new spinal fracture (study group), and 33,675 matched patients without fracture (comparison group). We respectively reviewed data of each participant for 3 years to assess the development of MD. The Cox proportional hazards model was used to determine the prevalence of MD, after adjusting for patient demographics, medications, surgical interventions, spinal cord involvement, and postfracture comorbidities. Results In total, 187 fracture patients (1.7%) and 281 nonfracture patients (0.8%) developed new-onset MD (hazard ratio [HR]:1.96, (95% confidence interval [CI]: 1.63-2.36)). Spinal cord involvement (HR: 2.96, 95% CI: 2.54-3.42) and postfracture comorbidities (HR: 3.51, 95% CI: 2.86-3.97) obviously increased the risk of MD. Conclusions Patients with spinal fracture (spinal cord involvement and postfracture comorbidities) were more likely to develop MD. Early surgical interventions (vertebroplasty) and medications (narcotics) may decrease the risk of MD.
URI:	http://dx.doi.org/10.1177/0300060520972885 https://www.webofscience.com/wos/woscc/full-record/WOS:000596090500001 https://ir.csmu.edu.tw:8080/handle/310902500/24673
Relation:	JOURNAL OF INTERNATIONAL MEDICAL RESEARCH ,2020 ,v48 ,issue 11
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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