中山醫學大學機構典藏 CSMUIR:Item 310902500/24661
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    题名: Significant Contribution of DNA Repair Human 8-Oxoguanine DNA N-Glycosylase 1 Genotypes to Renal Cell Carcinoma
    作者: Chang, WS;Shen, TC;Liao, JM;Tsai, YT;Hsia, TC;Wu, HC;Tsai, CW;Bau, DT
    关键词: hOGG1;genotype;polymorphism;renal cell carcinoma
    日期: 2020
    上传时间: 2022-08-09T08:05:58Z (UTC)
    出版者: DOVE MEDICAL PRESS LTD
    ISSN: 1178-6930
    摘要: Introduction: DNA repair systems play essential roles in genomic stability and carcinogenesis. Therefore, genotypes at DNA repair loci may contribute to the determination of personal susceptibility to cancers. The contribution of human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) genotypes to renal cell carcinoma (RCC) is largely unknown. This study aimed to evaluate the contributions of hOGG1 rs1052133 genotypes to the RCC risk. Methods: We evaluated the contribution of hOGG1 rs1052133 (G/C) genotypes among 118 cases and 590 controls and analyzed the interactions of hOGG1 genotypes with smoking, alcohol drinking, hypertension, and diabetes status. Results: The hOGG1 rs1052133 CC genotype was significantly associated with a decreased RCC risk compared with that of the GG genotype (odds ratio [OR] = 0.25, 95% confidence interval [CI] = 0.09-0.72, p = 0.0049). The frequency of the rs1052133 C allele was significantly low in the RCC group (22.5% vs 31.2%; OR = 0.64; 95% CI = 0.46-0.89, p = 0.0074). Stratifying the analysis according to smoking, alcohol drinking, and diabetes status revealed no difference in the rs1052133 genotype distribution among these subgroups. A significant differential distribution of rs1052133 genotypes was observed among subjects with hypertension. Conclusion: The CC genotype of rs1052133 may play a role in determining RCC susceptibility among Taiwanese people and may serve as a biomarker of RCC, particularly in patients with hypertension.
    URI: http://dx.doi.org/10.2147/OTT.S231733
    https://www.webofscience.com/wos/woscc/full-record/WOS:000515069000001
    https://ir.csmu.edu.tw:8080/handle/310902500/24661
    關聯: ONCOTARGETS AND THERAPY ,2020 ,v13 ,p1583-1591
    显示于类别:[中山醫學大學研究成果] 期刊論文

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