Suppression of oral cancer by induction of cell cycle arrest and apoptosis using Juniperus communis extract

doi:10.1042/BSR20202083

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24638

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題名:	Suppression of oral cancer by induction of cell cycle arrest and apoptosis using Juniperus communis extract
作者:	Lee, CC;Hsiao, CY;Lee, SC;Huang, XF;Chang, KF;Lee, MS;Hsieh, MC;Tsai, NM
日期:	2020
上傳時間:	2022-08-09T08:05:35Z (UTC)
出版者:	PORTLAND PRESS LTD
ISSN:	0144-8463
摘要:	The oral cancer incidence rate is slowly increasing and is now the fifth leading cause of cancer-related death due to its high metastasis and recurrence rate. Juniperus communis is used as a traditional Chinese medicine and has been proven to have anti-cancer activity against neuroblastomas. In the present study, we further investigated the anti-cancer mechanisms of J. communis extract (JCo) on oral cancer and evaluated the synergistic effects of JCo combined with 5-fluorouracil (5-FU). We found that JCo inhibited oral cancer cell growth, and that JCo might be less cytotoxic to normal cells than to cancer cells. After JCo treatment, cell cycle arrest was observed at the G(0)/G(1) phase through modulation of p53/p21 and Rb signaling. JCo also caused an increase in the sub-G(1) phase and cell apoptosis via the intrinsic and extrinsic apoptosis pathways. JCo combined with 5-FU presented a synergistic effect to reduce cell viability. In conclusion, JCo inhibited oral cancer cell growth by inducing cell cycle arrest and activating cell apoptosis, and JCo significantly synergized with 5-FU. JCo might have the potential to be an adjuvant and a new therapeutic drug for oral cancer treatment.
URI:	http://dx.doi.org/10.1042/BSR20202083 https://www.webofscience.com/wos/woscc/full-record/WOS:000582744900001 https://ir.csmu.edu.tw:8080/handle/310902500/24638
關聯:	BIOSCIENCE REPORTS ,2020 ,v40
顯示於類別:	[中山醫學大學研究成果] 期刊論文

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