Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway

doi:10.1002/tox.23059

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24623

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題名:	Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway
作者:	Yu, CL;Yu, YL;Yang, SF;Hsu, CE;Lin, CL;Hsieh, YH;Chiou, HL
關鍵詞:	ERK;hepatocellular carcinoma cells;metastatsis;MMP1;praeruptorin A
日期:	2021
上傳時間:	2022-08-09T08:05:21Z (UTC)
出版者:	WILEY
ISSN:	1520-4081
摘要:	Praeruptorin A (PA) is one of the active ingredients found in the dried root of Peucedanum praeruptorum Dunn, has been reported to possess anticancer effects against various types of cancer. However, the effect of PA on human hepatocellular carcinoma (HCC) remains uncleared. In this study, our results indicated that PA did not induce cytotoxicity or alter cell cycle distribution in human HCC cells (Huh-7, SK-Hep-1, and PLC/PRF/5 cells). Instead, PA inhibited the migration and invasion of human HCC cells while downregulating the expression of matrix metalloproteinase-1 (MMP1) and activating the extracellular signal-regulated kinase (ERK) signaling pathways. Furthermore, blocking the ERK signaling pathway through siERK restored the expression of MMP1 and the invasive ability of PA-treated HCC cells. In conclusion, our results demonstrate the antimetastatic activity of PA against human HCC cells, supporting its potential as a therapeutic agent of HCC treatments.
URI:	http://dx.doi.org/10.1002/tox.23059 https://www.webofscience.com/wos/woscc/full-record/WOS:000591378700001 https://ir.csmu.edu.tw:8080/handle/310902500/24623
關聯:	ENVIRONMENTAL TOXICOLOGY ,2021 ,v36 ,issue 4 ,p540-549
顯示於類別:	[中山醫學大學研究成果] 期刊論文

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