Effect of Cognitive Disability and Ambulation Status on Functioning in Moderate-to-Advanced Parkinson Disease

doi:10.3389/fneur.2019.01360

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24622

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24622

Title:	Effect of Cognitive Disability and Ambulation Status on Functioning in Moderate-to-Advanced Parkinson Disease
Authors:	Wang, CY;Chan, L;Wu, D;Chi, WC;Yen, CF;Liao, HF;Hong, CT;Liou, TH
Keywords:	Parkinson's disease;disability;cognition;ambulation;WHODAS 2;0
Date:	2020
Issue Date:	2022-08-09T08:05:21Z (UTC)
Publisher:	FRONTIERS MEDIA SA
ISSN:	1664-2295
Abstract:	Background: As the disease progresses to moderate to advanced stages, people with Parkinson's disease (PwP) are likely to have various degrees of disability due to the motor and non-motor symptoms, such as ambulatory difficulty and cognitive impairment. The objective of this study was to investigate the impact of cognition and ambulation status on the functioning and disability of PwP using the World Health Orgnaization Disability Assessment Schedule 2.0 (WHODAS 2.0). Materials and Methods: A group of 10,581 PwP with Hoehn and Yahr Staging 3 and above were collected from a database of disability evaluation and functional assessment using the Taiwan Data Bank of Persons with Disability between July 2012 and October 2018. WHODAS 2.0 was administered and all PwP were grouped based on their ambulatory status, which was assessed by 3-m back and forth walk and cognitive ability, assessed by WHODAS 2.0 first domain with cut-off level at 58. Results: Non-ambulation and cognitive disability contributed independently to disability in all aspects of WHODAS 2.0 survey, including self-care, getting along with others, performing life activities and participation in society. Compared to ambulation status, cognitive disability had a greater negative impact on functioning in all aspects. Conclusion: Cognitive disability was associated with greater disability in moderate to advanced PwP than non-ambulatory status. The results of this study may indicate that cognition preservation is essential to ameliorate functional impairment and disability in moderate to advanced PwP.
URI:	http://dx.doi.org/10.3389/fneur.2019.01360 https://www.webofscience.com/wos/woscc/full-record/WOS:000508835900001 https://ir.csmu.edu.tw:8080/handle/310902500/24622
Relation:	FRONTIERS IN NEUROLOGY ,2020 ,v10
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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