Indocyanine green fluorescence method for sentinel lymph node biopsy in breast cancer

doi:10.1016/j.asjsur.2020.02.003

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24619

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题名:	Indocyanine green fluorescence method for sentinel lymph node biopsy in breast cancer
作者:	Lin, J;Lin, LS;Chen, DR;Lin, KJ;Wang, YF;Chang, YJ
关键词:	Breast neoplasms;Indocyanine green;Blue dye;Sentinel lymph node biopsy
日期:	2020
上传时间:	2022-08-09T08:05:18Z (UTC)
出版者:	ELSEVIER SINGAPORE PTE LTD
ISSN:	1015-9584
摘要:	Background/Objective: Breast biopsy and analysis of sentinel lymph nodes (SLNs) accurately predict tumor status in the affected basin and help in avoiding unnecessary axillary lymph node dissection, which is associated with remarkable morbidity risk. Blue dye and radioisotope are the most widely used mapping agents, but non-radioactive tracers of comparable accuracy warrant further investigation. This study aimed to investigate utilization of indocyanine green (ICG) fluorescence in sentinel node localization compared with blue dye and to assess the incremental value of ICG. Methods: A total of 39 consecutive patients underwent sentinel lymph node biopsy (SLNB) (40 cases: 38 unilateral and 1 bilateral) with combined blue dye and ICG for localization. The obtained fluorescence images of the lymphatic system were investigated. Results: All 84 lymph nodes removed in 40 procedures were identified by ICG, but only 37 were identified by blue dye. The ICG method identified an average of 2.1 SLNs in 39 of 40 cases with a detection rate of 97.5%, but only 0.93 SLN per case with blue dye. Subcutaneous lymphatic channel patterns were also detected by fluorescent imaging in 37 procedures, which all revealed lymphatic drainage toward the axilla except in one case with internal mammary pathway. Conclusion: This study demonstrated the accuracy and safety of ICG for SLNB and its superiority to blue dye method in SLN localization. Therefore, ICG fluorescence method is safe and effective addition in breast clinical settings, wherein blue dye alone is used. (C) 2020 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V.
URI:	http://dx.doi.org/10.1016/j.asjsur.2020.02.003 https://www.webofscience.com/wos/woscc/full-record/WOS:000596376000003 https://ir.csmu.edu.tw:8080/handle/310902500/24619
關聯:	ASIAN JOURNAL OF SURGERY ,2020 ,v43 ,issue 12 ,p1149-1153
显示于类别:	[中山醫學大學研究成果] 期刊論文

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