Relationship between Helicobacter pylori infection and psoriasis: a nationwide population-based longitudinal cohort study

doi:10.1097/MD.0000000000020632

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24618

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24618

Title:	Relationship between Helicobacter pylori infection and psoriasis: a nationwide population-based longitudinal cohort study
Authors:	Wu, MC;Ma, KSK;Chen, HH;Huang, JY;Wei, JCC
Keywords:	cohort study;Helicobacter pylori;population-based;psoriasis
Date:	2020
Issue Date:	2022-08-09T08:05:17Z (UTC)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
ISSN:	0025-7974
Abstract:	Background: In the current literature, studies assessing the role of Helicobacter pylori (HP) infection in psoriasis have reported conflicting data. Therefore, we investigated the association between HP infection and psoriasis using a nationwide population-based longitudinal cohort study. Methods: We identified 41,539 patients with HP infection and 83,078 matched controls between 2000 and 2013 from the Longitudinal Health Insurance Research Database of the National Health Insurance Research Database in Taiwan. Propensity score analysis was used to match age, sex, comorbidities, and medical visits at a ratio of 1:2. Multiple Cox regression analysis was used to estimate the adjusted hazard ratio of psoriasis. Furthermore, sensitivity tests and a stratified analysis were conducted. Results: The incidence rates of psoriasis did not differ significantly between the HP and control cohorts (4.58 vs 4.20 per 100,000 person-months, crude relative risk: 1.092, 95% confidence interval: 0.917-1.302). After multivariate adjustment, no significant difference in psoriasis risk was observed in patients with HP infection (adjusted hazard ratio: 1.081, 95% confidence interval: 0.907-1.288). Risk of psoriasis was significantly higher in men and the elderly, and in those with diabetes, hyperlipidemia, chronic obstructive pulmonary disease, or tuberculosis. Stratified analysis also confirmed that HP infection was not correlated with an increased risk of psoriasis based on follow-up duration, sex, and age. Conclusion: This retrospective population-based longitudinal cohort study, conducted in Taiwan, found no association between HP infection and risk of psoriasis. Further research may be warranted.
URI:	http://dx.doi.org/10.1097/MD.0000000000020632 https://www.webofscience.com/wos/woscc/full-record/WOS:000549881200056 https://ir.csmu.edu.tw:8080/handle/310902500/24618
Relation:	MEDICINE ,2020 ,v99 ,issue 24
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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