中山醫學大學機構典藏 CSMUIR:Item 310902500/24599
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    题名: Blood-Based SOX2-Promoter Methylation in Relation to Exercise and PM2.5 Exposure among Taiwanese Adults
    作者: Su, CL;Tantoh, DM;Chou, YH;Wang, L;Ho, CC;Chen, PH;Lee, KJ;Nfor, ON;Hsu, SY;Liang, WM;Liaw, YP
    关键词: exercise;PM2.5;SOX2;methylation;Taiwan Biobank
    日期: 2020
    上传时间: 2022-08-09T08:04:59Z (UTC)
    出版者: MDPI
    摘要: Increased ventilation during exercise in polluted areas could trigger airway inflammation. We evaluated blood DNA methylation of the SOX2-promoter region in relation to exercise and PM2.5 in Taiwanese adults. Data of 948 participants aged 30-70 years were retrieved from the Taiwan Biobank Database (2008-2015) and the Air Quality Monitoring Database (2006-2011). PM2.5 was positively associated with SOX2-promoter methylation (beta = 0.000216; p < 0.0001). The interaction between PM2.5 and exercise on SOX2-promoter methylation was significant (p = 0.0146). After stratification by exercise habits, PM2.5 was positively associated with SOX2 methylation in only individuals who did regular exercise (beta = 0.0003490; p < 0.0001). After stratification by exercise habits and residential areas, SOX2-promoter methylation levels in those who lived in the southern area were higher for both the regular exercise (beta = 0.00272; p = 0.0172) and no regular exercise groups (beta = 0.002610 and p = 0.0162). SOX2-promoter methylation levels in those who lived in the northern area and did regular exercise were lower; beta = -0.00314 (p = 0.0036). In conclusion, PM2.5 was positively associated with SOX2-promoter methylation in participants who did regular exercise. Living in the southern area was positively associated with SOX2-promoter methylation regardless of exercise habits.
    URI: http://dx.doi.org/10.3390/cancers12020504
    https://www.webofscience.com/wos/woscc/full-record/WOS:000522477300250
    https://ir.csmu.edu.tw:8080/handle/310902500/24599
    關聯: CANCERS ,2020 ,v12 ,issue 2
    显示于类别:[中山醫學大學研究成果] 期刊論文

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