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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/24553
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Title: | Children with allergic rhinitis and a risk of epilepsy: A nationwide cohort study |
Authors: | Pan, HH;Hung, TW;Tsai, JD;Chen, HJ;Liao, PF;Sheu, JN |
Keywords: | Allergic rhinitis;Mast cells activation;Brain inflammation;Epilepsy |
Date: | 2020 |
Issue Date: | 2022-08-09T08:04:14Z (UTC)
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Publisher: | W B SAUNDERS CO LTD |
ISSN: | 1059-1311 |
Abstract: | Purpose: Little is known about whether allergic disease is associated with a subsequent increased risk of childhood-onset epilepsy. We used a large, population-based cohort study to examine whether children with antecedent allergic rhinitis (AR) were associated with a subsequent increased risk of epilepsy. Methods: This retrospective population-based cohort study was conducted by using data from the 2000-2012 Taiwan's National Health Insurance Research Database. We enrolled 67,537 children aged 0-18 years diagnosed with AR and 67,537 age-and gender-matched children without the diagnosis of AR. The incidence rate (per 10,000 person-years) of epilepsy was calculated. We used Cox proportional hazards regression analysis to estimate hazard ratios (HRs) and 95 % confident interval (CI). Results: Of the 135,074 children included in the analyses, those with AR had a higher incidence rate of epilepsy (6.84 versus 3.95 per 10,000 person-years, p<0.001) and an earlier age at diagnosis of epilepsy than those without AR [8.54 (4.90) versus 9.33 (5.40) years, p=0.03)]. The Kaplan-Meier survival analysis demonstrated that the children with AR had a higher likelihood of developing epilepsy than those without AR (p<0.001). After adjusting for confounding factors in multivariate model, children with AR had a 76 % increased risk of epilepsy (HR 1.76, 95 % CI 1.51-2.04) than those without AR. Boys had a 21 % increased risk of epilepsy (HR 1.21, 95 % CI 1.05-1.40) than girls. Conclusions: These results suggest that children with AR were associated with an increased subsequent risk of epilepsy. |
URI: | http://dx.doi.org/10.1016/j.seizure.2020.01.015 https://www.webofscience.com/wos/woscc/full-record/WOS:000528189000009 https://ir.csmu.edu.tw:8080/handle/310902500/24553 |
Relation: | SEIZURE-EUROPEAN JOURNAL OF EPILEPSY ,2020 ,v76 ,p64-71 |
Appears in Collections: | [中山醫學大學研究成果] 期刊論文
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