Effect of early eradication therapy on systemic lupus erythematosus risk in patients with Helicobacter pylori infection: a nationwide population-based cohort study

doi:10.1177/0961203320923393

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24548

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24548

Title:	Effect of early eradication therapy on systemic lupus erythematosus risk in patients with Helicobacter pylori infection: a nationwide population-based cohort study
Authors:	Wu, MC;Huang, JY;Chen, HH;Wei, JCC
Keywords:	Helicobacter pylori;systemic lupus erythematosus;cohort study;population-based
Date:	2020
Issue Date:	2022-08-09T08:04:10Z (UTC)
Publisher:	SAGE PUBLICATIONS LTD
ISSN:	0961-2033
Abstract:	Background This study aimed to investigate whether early eradication therapy influences systemic lupus erythematosus (SLE) risk in patients with Helicobacter pylori (HP) infection. Methods We identified 41,653 patients with HP infection in Taiwan from 2000 to 2013. The patient population was divided into early (within three months) and late (after three months) eradication cohorts. age, sex, co-morbidities and medical visits were matched at a 1:1 ratio. Multiple Cox regression, sensitivity analysis and stratified analysis were used to estimate SLE adjusted hazard ratios (aHR). Results The relative risk of SLE was 0.75 (95% confidence interval 0.43-1.31) in the early eradication cohort. After multivariate adjustment, the SLE risk was non-significantly lower in the early eradication cohort than in the late eradication cohort (aHR = 0.74, 95% CI 0.42-1.29). Stratified analysis revealed that early eradication could significantly reduce SLE risk during the three-year follow-up period (aHR = 0.16, 95% CI 0.05-0.53, p for interaction = 0.0013). Compared to eradication within three months of diagnosis, eradication within 3-36 months and >36 months corresponded with SLE aHRs of 4.78 (95% CI 1.19-19.20) and 7.66 (95% CI 2.17-27.05), respectively, when the follow-up period was less than three years. Conclusion Early HP eradication could significantly reduce SLE risk, especially in the first three-year follow-up.
URI:	http://dx.doi.org/10.1177/0961203320923393 https://www.webofscience.com/wos/woscc/full-record/WOS:000534040000001 https://ir.csmu.edu.tw:8080/handle/310902500/24548
Relation:	LUPUS ,2020 ,v29 ,issue 7 ,p751-760
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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