Role of biomarkers and effect of FIP-fve in acute and chronic animal asthma models

doi:10.1016/j.jmii.2020.07.006

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24534

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24534

Title:	Role of biomarkers and effect of FIP-fve in acute and chronic animal asthma models
Authors:	Wu, CT;Lee, YT;Ku, MS;Lue, KH
Keywords:	Acute;Chronic;Asthma cytokines;Chemokines
Date:	2020
Issue Date:	2022-08-09T08:03:56Z (UTC)
Publisher:	ELSEVIER TAIWAN
ISSN:	1684-1182
Abstract:	Background: Asthma is a consequence of complex gene-environment interactions. Exploring the heterogeneity of asthma in different stages is contributing to our understanding of its pathogenesis and the development of new therapeutic strategies, especially in severe cases. Objective: This study aimed to further understand the relationship between manifestations of acute and chronic asthma and various endotypes, and explore the severity of lung inflammation, cell types, cytokine/chemokine differences, and the effects of FIP-fve. Materials and methods: Acute and chronic OVA-sensitization mouse asthma models, based on our previously published method, were used and FIP-fve was used to evaluate the effect on these two models. BALF cytokines/chemokines were detected according to the manufacturer's protocol. Results: Seventeen cytokine/chemokine secretions were higher in the chronic stage than in the acute stage. Whether in acute stage or chronic stage, the FIP-fve treatment groups had reduced airway hyperresponsiveness, infiltration of airway inflammatory cells, secretion of cytokines, chemokines by Th2 cells, and TNF-alpha, IL-8, IL-17, CXCL-1, CXCL-10, CCL-17, and CCL22, and it was also found that the Treg cell cytokine IL-10 had increased significantly. PCA (Principal Component Analysis) was also used to compare statistics and laboratory data to find the important biomarkers in different stages and after treatment with FIP-fve. Conclusions: There are many different immune responses in the different stages of the asthma process. Drug treatment at the appropriate times might help reduce the worsening of asthma. Copyright (C) 2020, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
URI:	http://dx.doi.org/10.1016/j.jmii.2020.07.006 https://www.webofscience.com/wos/woscc/full-record/WOS:000600480500019 https://ir.csmu.edu.tw:8080/handle/310902500/24534
Relation:	JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION ,2020 ,v53 ,issue 6 ,p996-1007
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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