Protective effect of nerolidol on lipopolysaccharide-induced acute lung injury through the inhibition of NF-kappa B activation by the reduction of p38 MAPK and JNK phosphorylation

doi:10.1016/j.jff.2020.103943

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24530

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24530

Title:	Protective effect of nerolidol on lipopolysaccharide-induced acute lung injury through the inhibition of NF-kappa B activation by the reduction of p38 MAPK and JNK phosphorylation
Authors:	Chen, SP;Su, CH;Huang-Liu, R;Lee, MW;Chiang, CY;Chen, WY;Chen, CJ;Wu, SW;Kuang, YH
Keywords:	Nerolidol;LPS;Acute lung injury;NF-kappa B;p38 MAPK;JNK
Date:	2020
Issue Date:	2022-08-09T08:03:52Z (UTC)
Publisher:	ELSEVIER
ISSN:	1756-4646
Abstract:	Acute lung injury (ALI) is a severe syndrome, and there are no effective therapeutic appropriate medicines. Nerolidol, which exists in the essential oils of aromatic plants and flowers, exhibits antioxidative and anti-inflammatory activities. The present study evaluated the potential protective effect of nerolidol in ALI and the related mechanism in lipopolysaccharide (LPS)-treated mice. Here, nerolidol inhibited the LPS-induced neutrophil and other leukocyte infiltration of the alveolar space. LPS increased cytokines, chemokines, and adhesion molecules, and proinflammatory protein production was inhibited by nerolidol. LPS-induced phosphorylation of NF-kappa B p65, p38 MAPK, JNK, ERK were inhibited by nerolidol. The inhibitory concentration of nerolidol for the phosphorylation of NF-kappa B p65 and its upstream factors, p38 MAPK and JNK, was similar to the inflammatory responses of ALI. In conclusion, nerolidol is a potential protective agent in ALI via the inhibition of NF-kappa B activation and its upstream factors phosphorylation of p38 MAPK and JNK.
URI:	http://dx.doi.org/10.1016/j.jff.2020.103943 https://www.webofscience.com/wos/woscc/full-record/WOS:000537713200009 https://ir.csmu.edu.tw:8080/handle/310902500/24530
Relation:	JOURNAL OF FUNCTIONAL FOODS ,2020 ,v69
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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