中山醫學大學機構典藏 CSMUIR:Item 310902500/24525
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    题名: Gout can increase the risk of periodontal disease in Taiwan
    作者: Chen, HH;Ho, CW;Hsieh, MC;Chen, CC;Hsu, SP;Lin, CL;Kao, CH
    关键词: Gout;periodontal disease;cohort study
    日期: 2020
    上传时间: 2022-08-09T08:03:47Z (UTC)
    出版者: TAYLOR & FRANCIS LTD
    ISSN: 0032-5481
    摘要: Objectives: To evaluate the risk of periodontal disease (PD) in gout patients. Methods: This retrospective cohort study was conducted using data from the Longitudinal Health Insurance Database 2000. The gout cohort included 31,759 patients newly diagnosed with gout from 2000 to 2012, and the comparison (nongout) cohort included 63,517 patients. Univariate and multivariable adjusted hazard ratios (aHRs), with corresponding 95% confidence intervals (CIs), were estimated using the Cox proportional hazard model for determining the occurrence of PD in both cohorts. We also measured the cumulative incidence of PD in these two cohorts using the Kaplan-Meier method and assessed the curve difference using the log-rank test. Results: The mean follow-up time was more than 6 years for both cohorts. The overall incidence rate of PD was significantly higher in the gout cohort than in the comparison cohort (5.04 vs 4.16 per 10,000 person-years; aHR = 1.13, 95% CI = 1.10-1.16). Only patients using colchicine had a significantly lower risk of PD (aHR = 0.85, 95% CI = 0.79-0.91). Conclusion: In our study, patients with gout showed an increased risk of PD, and treatment with colchicine could decrease the risk.
    URI: http://dx.doi.org/10.1080/00325481.2020.1757267
    https://www.webofscience.com/wos/woscc/full-record/WOS:000537020600001
    https://ir.csmu.edu.tw:8080/handle/310902500/24525
    關聯: POSTGRADUATE MEDICINE ,2020 ,v132 ,issue 6 ,p521-525
    显示于类别:[中山醫學大學研究成果] 期刊論文

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