中山醫學大學機構典藏 CSMUIR:Item 310902500/24518
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    题名: The quality of general movements in infants with complex congenital heart disease undergoing surgery in the neonatal period
    作者: Huisenga, DC;Van Bergen, AH;Sweeney, JK;Wu, YC;Hadders-Algra, M
    关键词: General Movements Assessment;Movement complexity;Complex congenital heart disease;Chronic hypoxaemia
    日期: 2020
    上传时间: 2022-08-09T08:03:39Z (UTC)
    出版者: ELSEVIER IRELAND LTD
    ISSN: 0378-3782
    摘要: Background: Advances in diagnostic technologies, surgical management, and perioperative care have increased survival for neonates with complex congenital heart disease (CCHD). The success of these advances exposed a heightened risk of brain injury and developmental disabilities. The General Movements Assessment, a non-invasive method, may detect early neurodevelopmental impairments in high-risk infants. Aims: To examine whether infants with CCHD undergoing neonatal surgery have higher prevalence of atypical general movements (GMs) than a reference group, and whether single ventricle physiology with systemic oxygen saturations < 90% increases risk for atypical GMs. Methods: Serial General Movements Assessment (GMA) in a cohort of infants with CCHD (n = 74) at writhing (term-6 weeks) and fidgety (7-17 weeks) GM-age. GMA focused on the presence of definitely abnormal GM-complexity and absent fidgety movements. Single GMAs at 3 months were available from a reference sample of Dutch infants (n = 300). Regression analyses examined relationships between cardiac characteristics and definitely abnormal GM-complexity. Results: Higher prevalence of definitely abnormal GM-complexity in infants with CCHD compared to reference infants (adjusted OR 5.938, 95% CI 2.423-14.355), single ventricle CCHD increased the risk. Occurrence of absent fidgety movements was similar in infants with CCHD and reference infants (adjusted OR 0.475, 95% CI 0.058-3.876). Systemic postoperative oxygen saturations < 90% was associated with higher risk of definitely abnormal GM-complexity at fidgety (adjusted OR 16.445 95% CI 1.149-235.281), not at writhing age. Conclusions: Infants with CCHD, especially those with single ventricle CCHD, are at increased risk of definitely abnormal GM-complexity. GMA at fidgety age is recommended.
    URI: http://dx.doi.org/10.1016/j.earlhumdev.2020.105167
    https://www.webofscience.com/wos/woscc/full-record/WOS:000595328200016
    https://ir.csmu.edu.tw:8080/handle/310902500/24518
    關聯: EARLY HUMAN DEVELOPMENT ,2020 ,v151
    显示于类别:[中山醫學大學研究成果] 期刊論文

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