中山醫學大學機構典藏 CSMUIR:Item 310902500/24514
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    题名: Enhanced anticancer activity and endocytic mechanisms by polymeric nanocarriers ofn-butylidenephthalide in leukemia cells
    作者: Huang, XF;Chen, PT;Lin, YL;Lee, MS;Chang, KF;Liao, KW;Sheu, GT;Hsieh, MC;Tsai, NM
    关键词: Leukemia;Polycationic liposome containing PEI and polyethylene glycol complex (LPPC);n-Butylidenephthalide (BP);Cell apoptosis;Cell cycle
    日期: 2021
    上传时间: 2022-08-09T08:03:35Z (UTC)
    出版者: SPRINGER INTERNATIONAL PUBLISHING AG
    ISSN: 1699-048X
    摘要: Purpose The purpose of this study was to investigate the antitumor mechanisms ofn-butylidenephthalide (BP) and to further examine the delivery efficacy of polycationic liposome containing PEI and polyethylene glycol complex (LPPC)-encapsulated BP in leukemia cells. Methods MTS, flow cytometric and TUNEL assays were performed to assess cell viability and apoptosis. BP and BP/LPPC complex delivery efficiency was analyzed by full-wavelength fluorescent scanner and fluorescence microscope. The expressions of cell cycle- and apoptosis-related proteins were conducted by Western blotting. Results The results showed that BP inhibited leukemia cell growth by inducing cell cycle arrest and cell apoptosis. LPPC-encapsulated BP rapidly induced endocytic pathway activation, resulting in the internalization of BP into leukemia cells, causing cell apoptosis within 1 h. Conclusions LPPC encapsulation enhanced the cytotoxic activity of BP and did not influence the effects of BP induction that suggested LPPC-encapsulated BP might be developed as anti-leukemia drugs in future.
    URI: http://dx.doi.org/10.1007/s12094-020-02500-w
    https://www.webofscience.com/wos/woscc/full-record/WOS:000573402400001
    https://ir.csmu.edu.tw:8080/handle/310902500/24514
    關聯: CLINICAL & TRANSLATIONAL ONCOLOGY ,2021 ,v23 ,issue 6 ,p1142-1151
    显示于类别:[中山醫學大學研究成果] 期刊論文

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