Symptomatic cholelithiasis patients have an increased risk of pancreatic cancer: A population-based study

doi:10.1111/jgh.15234

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24511

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24511

Title:	Symptomatic cholelithiasis patients have an increased risk of pancreatic cancer: A population-based study
Authors:	Wang, CC;Tseng, MH;Wu, SW;Yang, TW;Chen, HY;Sung, WW;Su, CC;Wang, YT;Chen, WL;Lai, HC;Lin, CC;Tsai, MC
Keywords:	cholecystectomy;endoscopic papillary balloon dilatation;endoscopic sphincterotomy;pancreatic cancer
Date:	2021
Issue Date:	2022-08-09T08:03:32Z (UTC)
Publisher:	WILEY
ISSN:	0815-9319
Abstract:	Background and Aim Pancreatic cancer is a fatal disease; currently, the risk factor survey is not suitable for sporadic pancreatic cancer, which has neither family history nor the genetic analysis data. The aim of the present study was to evaluate the roles of cholelithiasis and cholelithiasis treatments on pancreatic cancer risk. Methods Symptomatic adult patients with an index admission of cholelithiasis were selected from one million random samples obtained between January 2005 and December 2009. The control group was matched with a 1:1 ratio for sex, age, chronic pancreatitis, and pancreatic cystic disease. Subsequent pancreatic cancer, which we defined as pancreatic cancer that occurred >= 6 months later, and total pancreatic cancer events were calculated in the cholelithiasis and control groups. The cholelithiasis group was further divided into endoscopic sphincterotomy/endoscopic papillary balloon dilatation, cholecystectomy, endoscopic sphincterotomy/endoscopic papillary balloon dilatation and cholecystectomy, and no-intervention groups for evaluation. Results The cholelithiasis group and the matched control group included 8265 adults. The cholelithiasis group contained 86 cases of diagnosed pancreatic cancer, and the control group contained 8 cases (P < 0.001). The incidence rate ratio (IRR) of subsequent pancreatic cancer was significantly higher in the cholelithiasis group than in the control group (IRR: 5.28,P < 0.001). The IRR of subsequent pancreatic cancer was higher in the no-intervention group comparing with cholecystectomy group (IRR = 3.21,P = 0.039) but was similar in other management subgroups. Conclusion Symptomatic cholelithiasis is a risk factor for pancreatic cancer; the risk is similar regardless of the intervention chosen for cholelithiasis.
URI:	http://dx.doi.org/10.1111/jgh.15234 https://www.webofscience.com/wos/woscc/full-record/WOS:000571746700001 https://ir.csmu.edu.tw:8080/handle/310902500/24511
Relation:	JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ,2021 ,v36 ,issue 5 ,p1187-1196
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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