Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial

doi:10.3390/antiox9090823

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Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24498

Title:	Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial
Authors:	Ho, CC;Chang, PS;Chen, HW;Lee, PF;Chang, YC;Tseng, CY;Lin, PT
Keywords:	ubiquinone supplementation;athletes;glycaemia;antioxidant;sport nutrition
Date:	2020
Issue Date:	2022-08-09T08:03:19Z (UTC)
Publisher:	MDPI
Abstract:	The aim of this study is to investigate the glycemic profile, oxidative stress, and antioxidant capacity in athletes after 12 weeks of ubiquinone supplementation. It was a double-blinded, randomized, parallel, placebo-controlled study. Thirty-one well-trained college athletes were randomly assigned to ubiquinone (300 mg/d, n = 17) or placebo group (n = 14). The glycemic profile [fasting glucose, glycated hemoglobin (HbA1c), homeostatic model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI)], plasma and erythrocyte malondialdehyde (MDA), total antioxidant capacity (TAC), and ubiquinone status were measured. After supplementation, the plasma ubiquinone concentration was significantly increased (p < 0.05) and the level of erythrocyte MDA was significantly lower in the ubiquinone group than in the placebo group (p < 0.01). There was a significant correlation between white blood cell (WBC) ubiquinone and glycemic parameters [HbA1c, r = -0.46, p < 0.05; HOMA-IR, r = -0.67, p < 0.01; QUICKI, r = 0.67, p < 0.01]. In addition, athletes with higher WBC ubiquinone level (>= 0.5 nmol/g) showed higher erythrocyte TAC and QUICKI and lower HOMA-IR. In conclusion, we demonstrated that athletes may show a better antioxidant capacity with higher ubiquinone status after 12 weeks of supplementation, which may further improve glycemic control.
URI:	http://dx.doi.org/10.3390/antiox9090823 https://www.webofscience.com/wos/woscc/full-record/WOS:000581678700001 https://ir.csmu.edu.tw:8080/handle/310902500/24498
Relation:	ANTIOXIDANTS ,2020 ,v9 ,issue 9
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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