中山醫學大學機構典藏 CSMUIR:Item 310902500/24493
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    题名: Dipeptidyl peptidase-4 inhibitor treatment could decreaseKlebsiella pneumoniaepneumonia in patients with type 2 diabetes
    作者: Chen, HH;Chen, CC;Ho, CW;Hsieh, MC;Hsu, SP;Lin, CL;Kao, CH
    关键词: Dipeptidyl peptidase-4 inhibitor (DPP4i);klebsiella pneumoniae (KP);diabetes;cohort study
    日期: 2020
    上传时间: 2022-08-09T08:03:15Z (UTC)
    出版者: TAYLOR & FRANCIS LTD
    ISSN: 0032-5481
    摘要: Objectives To investigate the effect of dipeptidyl peptidase-4 inhibitor (DPP4i) forKlebsiella pneumoniae(KP) pneumonia in patients with diabetes. Patients and methods Patients newly diagnosed with type 2 diabetes from 2009 to 2012 were recruited for this population-based and observational study. Diabetes complications severity index (DCSI) score and defined daily dose (DDD) were used for analysis. The multivariable Cox proportional hazards models were used to estimate the risk of KP pneumonia by DPP4i use, with adjustments for propensity score. The Kaplan-Meier method with the log-rank test was used to estimate the risk of KP pneumonia for DPP4i users. Results 34774 patients were included. The incidence rate of KP pneumonia in DDP4i users was 1.51 per 1000 person-years and that for the comparison was 2.25 per 1000 person-years. DDP4i users also had a significantly lower cumulative incidence of KP pneumonia (log-rank test p-value = 0.03). DDP4i users had a significantly lower risk of developing KP pneumonia compared with nonusers (adjusted HR = 0.67, 95% CI = 0.48-0.95). Conclusions For public health issue with type2 diabetes and infection, DPP4i use decreased KP pneumonia. Male gender, patients with co-morbidities, patients with higher DSCI score and higher DDD of DPP4i were observed to decrease KP pneumonia infection in our analysis. The possible role of DPP4i causing immunological disturbances should be considered.
    URI: http://dx.doi.org/10.1080/00325481.2020.1793520
    https://www.webofscience.com/wos/woscc/full-record/WOS:000550117400001
    https://ir.csmu.edu.tw:8080/handle/310902500/24493
    關聯: POSTGRADUATE MEDICINE ,2020 ,v132 ,issue 8 ,p714-719
    显示于类别:[中山醫學大學研究成果] 期刊論文

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