Effect of Cobalt Precursors on Cobalt-Hydroxyapatite Used in Bone Regeneration and MRI

doi:10.1177/0022034519897006

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24482

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24482

Title:	Effect of Cobalt Precursors on Cobalt-Hydroxyapatite Used in Bone Regeneration and MRI
Authors:	Lin, WC;Chuang, CC;Yao, C;Tang, CM
Keywords:	in vitro T2-weighted images;alveolar bone regeneration;biomaterial;biocompatibility;ceramics;cobalt-substituted hydroxyapatite (COHA)
Date:	2020
Issue Date:	2022-08-09T08:03:04Z (UTC)
Publisher:	SAGE PUBLICATIONS INC
ISSN:	0022-0345
Abstract:	In clinical dentistry practice, supplemental bone surgery or jawbone defect after tooth extraction must be assisted by a bone-filling material. Cobalt-substituted hydroxyapatite (COHA) effectively promotes bone cell growth, reduces the inflammatory response, and is an antibacterial agent. COHA can therefore be used as an alveolar bone-filling material or guided bone regeneration membrane. Meanwhile, COHA can be used in magnetic resonance imaging (MRI) with negative contrast agents and targeting materials without causing metal interference with the image. Hence, COHA has received increasing amounts of attention in recent years. However, the influence of different cobalt precursors on the synthesized COHA is still unknown. Therefore, COHA synthesized from 3 cobalt precursors (cobalt chloride, cobalt nitrate, and cobalt sulfate) was compared in this study. The results show that COHA synthesized by the precursor with the smallest anion radius, cobalt chloride, has a larger particle size (239 nm) and a higher cobalt ion substitution rate (15.6%). When the cobalt ion substitution rate increases, the MRI has a stronger contrast. Bioactivity data indicate that COHAC is more susceptible to degradation and therefore releases more cobalt ions to contribute to the differentiation of bone cells. Based on these studies, COHAC prepared with the cobalt chloride precursor has a higher cobalt ion substitution rate, faster degradation rate, better image contrast, and better bioactivity. It is therefore the preferred choice of bone-filling material for alveolar bone regeneration.
URI:	http://dx.doi.org/10.1177/0022034519897006 https://www.webofscience.com/wos/woscc/full-record/WOS:000507735100001 https://ir.csmu.edu.tw:8080/handle/310902500/24482
Relation:	JOURNAL OF DENTAL RESEARCH ,2020 ,v99 ,issue 3 ,p277-284
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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