中山醫學大學機構典藏 CSMUIR:Item 310902500/24475
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    题名: The Impact of HMGB1 Polymorphisms on Prostate Cancer Progression and Clinicopathological Characteristics
    作者: Chou, YE;Yang, PJ;Lin, CY;Chen, YY;Chiang, WL;Lin, PX;Huang, ZY;Huang, M;Ho, YC;Yang, SF
    关键词: prostate cancer;HMGB1;polymorphism
    日期: 2020
    上传时间: 2022-08-09T08:02:56Z (UTC)
    出版者: MDPI
    摘要: Prostate cancer is one of the major cancers of the genitourinary tract. High-mobility group box 1 (HMGB1) was suggested as a promising therapeutic target for prostate cancer. In this study, we aim to elucidate the associations of HMGB1 single nucleotide polymorphisms (SNPs) with prostate cancer susceptibility and clinicopathological characteristics. The HMGB1 SNPs rs1412125, rs2249825, rs1045411, and rs1360485 in 579 prostate cancer patients and 579 cancer-free controls were analyzed with real-time polymerase chain reactions (real-time PCR). All of the data were evaluated with SAS statistical software. Our results showed that the HMGB1 rs1045411 T allele genotype was significantly associated with advanced pathologic T stage (odds ratio (OR) = 1.433, 95% confidence interval (CI) = 1.021-2.012; p = 0.037) and pathologic N1 stage (OR = 2.091, 95% CI = 1.160-3.767; p = 0.012), and the rs1360485 polymorphic CT + TT genotype was associated with pathologic Gleason grade group (4 + 5) (OR = 1.583, 95% CI = 1.017-2.462; p = 0.041), pathologic T stage (3 + 4) (OR = 1.482, 95% CI = 1.061-2.070; p = 0.021), and pathologic N1 stage (OR = 2.131, 95% CI = 1.178-3.852; p = 0.011) compared with their wild-type carriers. In conclusion, our results revealed that the HMGB1 SNPs were associated with the clinical status of prostate cancer. The HMGB1 SNPs may have the potential to predict prostate cancer disease progression.
    URI: http://dx.doi.org/10.3390/ijerph17197247
    https://www.webofscience.com/wos/woscc/full-record/WOS:000586563500001
    https://ir.csmu.edu.tw:8080/handle/310902500/24475
    關聯: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH ,2020 ,v17 ,issue 19
    显示于类别:[中山醫學大學研究成果] 期刊論文

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