The Impact of HMGB1 Polymorphisms on Prostate Cancer Progression and Clinicopathological Characteristics

doi:10.3390/ijerph17197247

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24475

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24475

Title:	The Impact of HMGB1 Polymorphisms on Prostate Cancer Progression and Clinicopathological Characteristics
Authors:	Chou, YE;Yang, PJ;Lin, CY;Chen, YY;Chiang, WL;Lin, PX;Huang, ZY;Huang, M;Ho, YC;Yang, SF
Keywords:	prostate cancer;HMGB1;polymorphism
Date:	2020
Issue Date:	2022-08-09T08:02:56Z (UTC)
Publisher:	MDPI
Abstract:	Prostate cancer is one of the major cancers of the genitourinary tract. High-mobility group box 1 (HMGB1) was suggested as a promising therapeutic target for prostate cancer. In this study, we aim to elucidate the associations of HMGB1 single nucleotide polymorphisms (SNPs) with prostate cancer susceptibility and clinicopathological characteristics. The HMGB1 SNPs rs1412125, rs2249825, rs1045411, and rs1360485 in 579 prostate cancer patients and 579 cancer-free controls were analyzed with real-time polymerase chain reactions (real-time PCR). All of the data were evaluated with SAS statistical software. Our results showed that the HMGB1 rs1045411 T allele genotype was significantly associated with advanced pathologic T stage (odds ratio (OR) = 1.433, 95% confidence interval (CI) = 1.021-2.012; p = 0.037) and pathologic N1 stage (OR = 2.091, 95% CI = 1.160-3.767; p = 0.012), and the rs1360485 polymorphic CT + TT genotype was associated with pathologic Gleason grade group (4 + 5) (OR = 1.583, 95% CI = 1.017-2.462; p = 0.041), pathologic T stage (3 + 4) (OR = 1.482, 95% CI = 1.061-2.070; p = 0.021), and pathologic N1 stage (OR = 2.131, 95% CI = 1.178-3.852; p = 0.011) compared with their wild-type carriers. In conclusion, our results revealed that the HMGB1 SNPs were associated with the clinical status of prostate cancer. The HMGB1 SNPs may have the potential to predict prostate cancer disease progression.
URI:	http://dx.doi.org/10.3390/ijerph17197247 https://www.webofscience.com/wos/woscc/full-record/WOS:000586563500001 https://ir.csmu.edu.tw:8080/handle/310902500/24475
Relation:	INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH ,2020 ,v17 ,issue 19
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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