中山醫學大學機構典藏 CSMUIR:Item 310902500/24474
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    题名: Effects of Cedrus atlantica extract on acute myeloid leukemia cell cycle distribution and apoptosis
    作者: Hung, PH;Hsieh, MC;Lee, SC;Huang, XF;Chang, KF;Chen, SY;Lee, MS;Tsai, NM
    关键词: Cedrus atlantica;Apoptosis;Cell cycle;Acute myeloid leukemia (AML)
    日期: 2020
    上传时间: 2022-08-09T08:02:54Z (UTC)
    出版者: SPRINGER
    ISSN: 0301-4851
    摘要: This study investigated the anti-leukemic effects of Cedrus atlantica extract (CAt extract) on cell cycle distribution and apoptosis in human acute myeloid leukemia (AML) cells. AML often occurs in older adults, accounting for 60% of the cases, and is likely to be resistant to chemotherapy due to multidrug resistance, resulting in early death during cancer treatment. With the increasing focus on prevention medicine, natural plant components are being used as a major source for the development of therapeutic drugs or functional foods to cure or alleviate the disease. Cedrus species are known to have anti-inflammatory, antimicrobial, antiviral, and anticancer effects; however, the anticancer effects of CAt extract have not been elucidated. In this study, CAt extract demonstrated an inhibitory effect on human leukemia cells in a concentration-dependent manner; CAt extract induced G(0)/G(1) phase arrest via restrained protein levels of p-Rb and cell cycle-related proteins. After CAt extract exposure, the extrinsic and intrinsic apoptotic pathways were activated through caspase-8, -9, and -3 cleavage. Additionally, CAt extract suppressed VEGF, MMP-2, and MMP-9 expression. This study demonstrated that CAt extract treatment significantly reduced cell growth, cell cycle arrest in the G(0)/G(1) phase, and induction of apoptosis, leading to leukemia cell death.
    URI: http://dx.doi.org/10.1007/s11033-020-05947-w
    https://www.webofscience.com/wos/woscc/full-record/WOS:000585843100001
    https://ir.csmu.edu.tw:8080/handle/310902500/24474
    關聯: MOLECULAR BIOLOGY REPORTS ,2020 ,v47 ,issue 11 ,p8935-8947
    显示于类别:[中山醫學大學研究成果] 期刊論文

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