Effects of Cedrus atlantica extract on acute myeloid leukemia cell cycle distribution and apoptosis

doi:10.1007/s11033-020-05947-w

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24474

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24474

Title:	Effects of Cedrus atlantica extract on acute myeloid leukemia cell cycle distribution and apoptosis
Authors:	Hung, PH;Hsieh, MC;Lee, SC;Huang, XF;Chang, KF;Chen, SY;Lee, MS;Tsai, NM
Keywords:	Cedrus atlantica;Apoptosis;Cell cycle;Acute myeloid leukemia (AML)
Date:	2020
Issue Date:	2022-08-09T08:02:54Z (UTC)
Publisher:	SPRINGER
ISSN:	0301-4851
Abstract:	This study investigated the anti-leukemic effects of Cedrus atlantica extract (CAt extract) on cell cycle distribution and apoptosis in human acute myeloid leukemia (AML) cells. AML often occurs in older adults, accounting for 60% of the cases, and is likely to be resistant to chemotherapy due to multidrug resistance, resulting in early death during cancer treatment. With the increasing focus on prevention medicine, natural plant components are being used as a major source for the development of therapeutic drugs or functional foods to cure or alleviate the disease. Cedrus species are known to have anti-inflammatory, antimicrobial, antiviral, and anticancer effects; however, the anticancer effects of CAt extract have not been elucidated. In this study, CAt extract demonstrated an inhibitory effect on human leukemia cells in a concentration-dependent manner; CAt extract induced G(0)/G(1) phase arrest via restrained protein levels of p-Rb and cell cycle-related proteins. After CAt extract exposure, the extrinsic and intrinsic apoptotic pathways were activated through caspase-8, -9, and -3 cleavage. Additionally, CAt extract suppressed VEGF, MMP-2, and MMP-9 expression. This study demonstrated that CAt extract treatment significantly reduced cell growth, cell cycle arrest in the G(0)/G(1) phase, and induction of apoptosis, leading to leukemia cell death.
URI:	http://dx.doi.org/10.1007/s11033-020-05947-w https://www.webofscience.com/wos/woscc/full-record/WOS:000585843100001 https://ir.csmu.edu.tw:8080/handle/310902500/24474
Relation:	MOLECULAR BIOLOGY REPORTS ,2020 ,v47 ,issue 11 ,p8935-8947
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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