中山醫學大學機構典藏 CSMUIR:Item 310902500/24467
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    题名: The risks of ubiquinone and beta-carotene deficiency and metabolic disorders in patients with oral cancer
    作者: Chan, MY;Lee, BJ;Chang, PS;Hsiao, HY;Hsu, LP;Chang, CH;Lin, PT
    关键词: Ubiquinone;beta-Carotene;Antioxidant vitamins;Metabolic disorders;Oral cancer
    日期: 2020
    上传时间: 2022-08-09T08:02:48Z (UTC)
    出版者: BMC
    摘要: BackgroundCancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with oral cancer according to tumor-node-metastasis (TNM) stages.MethodsA total of 194 patients with oral cancer were enrolled in this study. The patients were stratified for four groups according to cancer stages and that the statistics are comparisons across these groups. The levels of antioxidant vitamins (ubiquinone, beta -carotene, vitamin A and E), metabolic parameters, oxidative stress, antioxidant enzymes activity, and inflammatory markers were measured.ResultsMore than half of the subjects had high blood pressure, central obesity, hyperglycemia, and hyperlipidemia regardless of TNM stage. With regard to antioxidant vitamins status, 46 and 94% of patients had beta -carotene and ubiquinone deficiency, respectively. Patients in T3 and T4 stages had significantly lower antioxidant enzyme (catalase, p=0.03) activity and higher inflammatory markers levels (high sensitivity C-reactive protein and interleukin-6, p<0.01) than patients in the other stages. In addition, the level of <beta>-carotene was negatively associated with waist circumference, and ubiquinone was positively associated with the level of high-density lipoprotein cholesterol (p<0.05). Higher <beta>-carotene and ubiquinone levels were negatively associated with hypertriglyceridemia and the risk of metabolic syndrome (p<0.05).ConclusionsA high proportion of patients with oral cancer had ubiquinone or <beta>-carotene deficiency and metabolic disorders. The level of ubiquinone or beta -carotene was negatively associated with the risk of central obesity, hypertriglyceridemia, and metabolic syndrome. Since patients with oral cancer suffer from high oxidative stress and inflammation (particularly in the T3 and T4 stages), supplementation with antioxidant vitamins such as ubiquinone or beta -carotene could be preferentially applied.
    URI: http://dx.doi.org/10.1186/s12885-020-06839-9
    https://www.webofscience.com/wos/woscc/full-record/WOS:000531187700009
    https://ir.csmu.edu.tw:8080/handle/310902500/24467
    關聯: BMC CANCER ,2020 ,v20 ,issue 1
    显示于类别:[中山醫學大學研究成果] 期刊論文

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