中山醫學大學機構典藏 CSMUIR:Item 310902500/24462
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    题名: Interaction between Sex and LDLR rs688 Polymorphism on Hyperlipidemia among Taiwan Biobank Adult Participants
    作者: Liu, YT;Nfor, ON;Wang, L;Hsu, SY;Lung, CC;Tantoh, DM;Wu, MC;Chang, HR;Liaw, YP
    关键词: hyperlipidemia;sex;biobank;polymorphism
    日期: 2020
    上传时间: 2022-08-09T08:02:43Z (UTC)
    出版者: MDPI
    摘要: Hyperlipidemia is one of the strong risk factors for ischemic heart disease. Using the Taiwan Biobank (TWB) database, we evaluated the risk of hyperlipidemia and its interaction with sex and rs688 polymorphism on the low-density lipoprotein receptor (LDLR) gene. Data collection in the biobank started in 2008 and is ongoing. Data analysis was performed on the participants' data collected between 2008 and 2015. In general, 27.92% of the 9237 female participants and 32.65% of the 8690 male participants were identified with hyperlipidemia. Compared to the C/C genotype, C/T and T/T genotypes were not significant risk factors for hyperlipidemia (OR = 1.061, CI: 0.976-1.153 for C/T and OR = 1.052, CI: 0.845-1.309 for T/T genotype) in the general model. However, there was a significant interaction between sex and rs6888 on hyperlipidemia risk (p-interaction = 0.0321). With the male sex/CC genotype being the reference group, only the female sex/CT and T/T genotypes were closely associated with hyperlipidemia, with respective ORs of 1.153 (CI: 1.014-1.311) and 1.423 (CI: 1.056-1.917). Our data indicate that rs688 C/T and T/T genotypes may be associated with increased risk of hyperlipidemia in Taiwanese women. These findings may be relevant in lipid-modification therapy.
    URI: http://dx.doi.org/10.3390/biom10020244
    https://www.webofscience.com/wos/woscc/full-record/WOS:000522138500162
    https://ir.csmu.edu.tw:8080/handle/310902500/24462
    關聯: BIOMOLECULES ,2020 ,v10 ,issue 2
    显示于类别:[中山醫學大學研究成果] 期刊論文

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