中山醫學大學機構典藏 CSMUIR:Item 310902500/24449
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    题名: Interaction between Coffee Drinking and TRIB1 rs17321515 Single Nucleotide Polymorphism on Coronary Heart Disease in a Taiwanese Population
    作者: Liu, YT;Tantoh, DM;Wang, L;Nfor, ON;Hsu, SY;Ho, CC;Lung, CC;Chang, HR;Liaw, YP
    关键词: coffee drinking;TRIB1;rs17321515;CHD;Taiwan Biobank
    日期: 2020
    上传时间: 2022-08-09T08:02:30Z (UTC)
    出版者: MDPI
    摘要: A complex interplay of several genetic and lifestyle factors influence coronary heart disease (CHD). We determined the interaction between coffee consumption and the tribbles pseudokinase 1 (TRIB1) rs17321515 variant on coronary heart disease (CHD). Data on CHD were obtained from the National Health Insurance Research Database (NHIRD) while genotype data were collected from the Taiwan Biobank (TWB) Database. From the linked electronic health record data, 1116 individuals were identified with CHD while 7853 were control individuals. Coffee consumption was associated with a lower risk of CHD. The multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) was 0.84 (0.72-0.99). Association of CHD with the TRIB1 rs17321515 variant was not significant. The OR (95% CI) was 1.01 (0.72-0.99). There was an interaction between TRIB1 rs17321515 and coffee consumption on CHD risk (p for interaction = 0.0330). After stratification by rs17321515 genotypes, coffee drinking remained significantly associated with a lower risk of CHD only among participants with GG genotype (OR, 0.62; 95% CI, 0.45-0.85). In conclusion, consumption of coffee was significantly associated with a decreased risk of CHD among Taiwanese adults with the TRIB1 GG genotype.
    URI: http://dx.doi.org/10.3390/nu12051301
    https://www.webofscience.com/wos/woscc/full-record/WOS:000542272700229
    https://ir.csmu.edu.tw:8080/handle/310902500/24449
    關聯: NUTRIENTS ,2020 ,v12 ,issue 5
    显示于类别:[中山醫學大學研究成果] 期刊論文

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