中山醫學大學機構典藏 CSMUIR:Item 310902500/24414
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    题名: Urinary Exosomal MicroRNA Signatures in Nephrotic, Biopsy-Proven Diabetic Nephropathy
    作者: Lee, WC;Li, LC;Ng, HY;Lin, PT;Chiou, TTY;Kuo, WH;Lee, CT
    关键词: microRNA;diabetic nephropathy;nephrotic
    日期: 2020
    上传时间: 2022-08-09T08:01:54Z (UTC)
    出版者: MDPI
    摘要: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD). Elucidating the mechanisms underlying proteinuria in DKD is crucial because it is a common problem in DKD-related mortality and morbidity. MicroRNAs (miRs) associated with DKD have been detected in experimental diabetes models and in patients with both diabetes and CKD. Here, we aimed to investigate pathologic miRs in diabetic nephropathy (DN) by prospectively following six nephrotic, biopsy-proven isolated DN patients (enrolled between August 2015 and July 2017) for one year. The urinary exosomes were isolated at the time of the biopsy and the contained miRs were analyzed by next-generation sequencing. The results were compared to the control group, composed of age-, gender-, and CKD stage-matched patients with proteinuric CKD who did not present diabetes. Among the 72 identified miRs, we investigated eight (miR-188-5p, miR-150-3p, miR-760, miR-3677-3p, miR-548ah-3p, miR-548p, miR-320e, and miR-23c) exhibiting the strongest upregulation (13-15 fold) and two (miR-133a-3p and miR-153-3p) with the strongest downregulation (7-9 fold). The functional analysis of these miRs showed that they were involved in known and novel pathways of DN, supporting their pathologic roles. The bioinformatics-based prediction of the target genes of these miRs will inspire future research on the mechanisms underlying DN pathogenesis.
    URI: http://dx.doi.org/10.3390/jcm9041220
    https://www.webofscience.com/wos/woscc/full-record/WOS:000531821000327
    https://ir.csmu.edu.tw:8080/handle/310902500/24414
    關聯: JOURNAL OF CLINICAL MEDICINE ,2020 ,v9 ,issue 4
    显示于类别:[中山醫學大學研究成果] 期刊論文

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