中山醫學大學機構典藏 CSMUIR:Item 310902500/24383
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    题名: Prognostic Value of SDF-1 alpha Expression in Patients with Esophageal Squamous Cell Carcinoma Receiving Esophagectomy
    作者: Chen, YH;Li, SH;Lu, HI;Lo, CM
    关键词: SDF-1 alpha;esophageal cancer;squamous cell carcinoma;esophagectomy
    日期: 2020
    上传时间: 2022-08-09T08:01:25Z (UTC)
    出版者: MDPI
    摘要: Stromal cell-derived factor-1 alpha (SDF-1 alpha) is a chemokine that has been reported to be involved in tumor progression in several malignancies. This study aimed to evaluate the crucial role of SDF-1 alpha in patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy. A total of 169 patients with ESCC were identified, including overexpression of SDF-1 alpha in 60 patients and low expression of SDF-1 alpha in 109 patients by immunohistochemical analysis. Two ESCC cell lines, TE1 and KYSE30, were selected to evaluate the tumor cell proliferative effect of SDF-1 alpha. Univariate and multivariate analyses showed that high tumor (T) status, positive lymph node metastasis, tumors located in the upper esophagus, and SDF-1 alpha overexpression were significantly related to worse disease-free survival and overall survival. In addition, the two cell lines were treated with SDF-1 alpha, AMD3100 (an SDF-1 alpha -ligand receptor antagonist), and chemotherapeutic agents (cisplatin). Our in vitro study results showed that SDF-1 alpha promoted the proliferation of tumor cells, and blocking the SDF-1 alpha pathway displayed a growth inhibition effect in a dose-dependent manner. SDF-1 alpha plays an important role in the progression of ESCC and is an independent prognostic factor for ESCC patients who underwent esophagectomy.
    URI: http://dx.doi.org/10.3390/cancers12051067
    https://www.webofscience.com/wos/woscc/full-record/WOS:000539246000008
    https://ir.csmu.edu.tw:8080/handle/310902500/24383
    關聯: CANCERS ,2020 ,v12 ,issue 5
    显示于类别:[中山醫學大學研究成果] 期刊論文

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