中山醫學大學機構典藏 CSMUIR:Item 310902500/24381
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    题名: Association between coarse particulate matter (PM10-2.5) and nasopharyngeal carcinoma among Taiwanese men
    作者: Huang, HC;Tantoh, DM;Hsu, SY;Nfor, ON;Frank, CFL;Lung, CC;Ho, CC;Chen, CY;Liaw, YP
    日期: 2020
    上传时间: 2022-08-09T08:01:23Z (UTC)
    出版者: BMJ PUBLISHING GROUP
    ISSN: 1081-5589
    摘要: The nasopharyngeal tract traps mainly coarse particles in inhaled air. Soluble carcinogenic compounds, endotoxins, and trace metals contained in these particles are potential causes of inflammation and oxidative stress which could enhance carcinogenesis. The aim of this study was to determine the association between coarse particulate matter (PM10-2.5) and nasopharyngeal cancer (NPC). A total of 521,098 men (355 cases and 520,743 non-cases), aged >= 40 years were included in this study. Data were retrieved from the Taiwan Cancer Registry, the Adult Preventive Medical Services Database, and the Air Quality Monitoring Database. PM10-2.5 was significantly associated with a higher risk of NPC after adjusting for SO2, NOx, O-3, age, body mass index, smoking, alcohol drinking, betel nut chewing, exercise, hypertension, diabetes, and hyperlipidemia. With PM10-2.5<20.44 mu g/m(3) as the reference, the ORs and 95% CIs were 1.47; 1.03-2.11, 1.34; 0.94-1.91, and 1.68; 1.16-2.44 for 20.44 <= PM10-2.5<24.08, 24.08 <= PM10-2.5<29.27, and PM(10-2.5 >=)29.27 mu g/m(3), respectively. PM10-2.5 remained significantly associated with a higher risk of NPC after further adjustments were made for the aforementioned covariates and PM2.5. The ORs; 95% CIs were 1.42; 0.96 to 2.12, 1.41; 0.94 to 2.10, and 1.71; 1.10 to 2.66 for 20.44 <= PM10-2.5<24.08, 24.08 <= PM10-2.5<29.27, and PM10-2.5 >= 29.27 mu g/m(3), respectively. In conclusion, PM10-2.5 was significantly associated with a higher risk of NPC in Taiwanese men.
    URI: http://dx.doi.org/10.1136/jim-2019-001119
    https://www.webofscience.com/wos/woscc/full-record/WOS:000518228000014
    https://ir.csmu.edu.tw:8080/handle/310902500/24381
    關聯: JOURNAL OF INVESTIGATIVE MEDICINE ,2020 ,v68 ,issue 2 ,p419-424
    显示于类别:[中山醫學大學研究成果] 期刊論文

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