Association between coarse particulate matter (PM10-2.5) and nasopharyngeal carcinoma among Taiwanese men

doi:10.1136/jim-2019-001119

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24381

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24381

Title:	Association between coarse particulate matter (PM10-2.5) and nasopharyngeal carcinoma among Taiwanese men
Authors:	Huang, HC;Tantoh, DM;Hsu, SY;Nfor, ON;Frank, CFL;Lung, CC;Ho, CC;Chen, CY;Liaw, YP
Date:	2020
Issue Date:	2022-08-09T08:01:23Z (UTC)
Publisher:	BMJ PUBLISHING GROUP
ISSN:	1081-5589
Abstract:	The nasopharyngeal tract traps mainly coarse particles in inhaled air. Soluble carcinogenic compounds, endotoxins, and trace metals contained in these particles are potential causes of inflammation and oxidative stress which could enhance carcinogenesis. The aim of this study was to determine the association between coarse particulate matter (PM10-2.5) and nasopharyngeal cancer (NPC). A total of 521,098 men (355 cases and 520,743 non-cases), aged >= 40 years were included in this study. Data were retrieved from the Taiwan Cancer Registry, the Adult Preventive Medical Services Database, and the Air Quality Monitoring Database. PM10-2.5 was significantly associated with a higher risk of NPC after adjusting for SO2, NOx, O-3, age, body mass index, smoking, alcohol drinking, betel nut chewing, exercise, hypertension, diabetes, and hyperlipidemia. With PM10-2.5<20.44 mu g/m(3) as the reference, the ORs and 95% CIs were 1.47; 1.03-2.11, 1.34; 0.94-1.91, and 1.68; 1.16-2.44 for 20.44 <= PM10-2.5<24.08, 24.08 <= PM10-2.5<29.27, and PM(10-2.5 >=)29.27 mu g/m(3), respectively. PM10-2.5 remained significantly associated with a higher risk of NPC after further adjustments were made for the aforementioned covariates and PM2.5. The ORs; 95% CIs were 1.42; 0.96 to 2.12, 1.41; 0.94 to 2.10, and 1.71; 1.10 to 2.66 for 20.44 <= PM10-2.5<24.08, 24.08 <= PM10-2.5<29.27, and PM10-2.5 >= 29.27 mu g/m(3), respectively. In conclusion, PM10-2.5 was significantly associated with a higher risk of NPC in Taiwanese men.
URI:	http://dx.doi.org/10.1136/jim-2019-001119 https://www.webofscience.com/wos/woscc/full-record/WOS:000518228000014 https://ir.csmu.edu.tw:8080/handle/310902500/24381
Relation:	JOURNAL OF INVESTIGATIVE MEDICINE ,2020 ,v68 ,issue 2 ,p419-424
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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