Clinicomicrobiological profile, visual outcome and mortality of culture-proven endogenous endophthalmitis in Taiwan

doi:10.1038/s41598-020-69251-0

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24378

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24378

Title:	Clinicomicrobiological profile, visual outcome and mortality of culture-proven endogenous endophthalmitis in Taiwan
Authors:	Hsieh, MC;Chen, SN;Cheng, CY;Li, KH;Chuang, CC;Wu, JS;Lee, ST;Chiu, SL
Date:	2020
Issue Date:	2022-08-09T08:01:20Z (UTC)
Publisher:	NATURE PUBLISHING GROUP
ISSN:	2045-2322
Abstract:	This is a retrospective study in consecutive cases with cultured-proven endogenous endophthalmitis (EE) treated at the largest tertiary medical center in middle Taiwan in the past 10 years. 83 eyes of 70 patients were enrolled. The mean interval between systemic diseases to the diagnosis of EE was 8.84 +/- 6.94 days. The mean initial visual acuity (VA) in the logarithm of minimal angle of resolution (logMAR) was 1.63 +/- 0.87. Type 2 diabetes mellitus was the most common predisposing medical illness (N=53, 63.86%). The most common infectious sources were intra-abdominal abscess (N=36, 43.37%), and the second most reason was urinary tract infection. The causative pathogen was Gram-negative predominant (N=64, 77.11%). After aggressive treatment, 34.94% of eyes regain useful vision, and only six eyes underwent enucleation or evisceration. The binary multivariate logistic regression model revealed that female gender (95% CI 1.002-19.036, p=0.05, OR 4.37), initial VA logMAR (95% CI 0.089-0.550, p=0.01, OR 0.22), and more intravitreal injections (95% CI 0.368-0.927, p=0.023, OR 0.58) were independent risk factors influencing final outcomes. Based on the results mentioned above, early diagnosis is recommended to gain better outcomes. The mean interval between systemic diseases to the diagnosis of EE was 8.84 +/- 6.94 days in our sample population, clinicians should maintain a higher index of suspicion during this period when encountering patients with bacteremia or fungemia.
URI:	http://dx.doi.org/10.1038/s41598-020-69251-0 https://www.webofscience.com/wos/woscc/full-record/WOS:000556872700014 https://ir.csmu.edu.tw:8080/handle/310902500/24378
Relation:	SCIENTIFIC REPORTS ,2020 ,v10 ,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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