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https://ir.csmu.edu.tw:8080/ir/handle/310902500/24346
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Title: | Does inappropriate initial antibiotic therapy affect in-hospital mortality of patients in the emergency department with Escherichia coli and Klebsiella pneumoniae bloodstream infections? |
Authors: | Chen, FC;Ho, YN;Cheng, HH;Wu, CH;Change, MW;Su, CM |
Keywords: | bloodstream infection;E;coli;ESBL;inappropriate initial antibiotic therapy;in-hospital mortality;K;pneumoniae |
Date: | 2020 |
Issue Date: | 2022-08-09T08:00:48Z (UTC)
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Publisher: | SAGE PUBLICATIONS INC |
ISSN: | 0394-6320 |
Abstract: | Extended-spectrum beta -lactamase (ESBL)-positive bloodstream infection (BSI) is on the rise worldwide. The purpose of this study is to evaluate the impact of inappropriate initial antibiotic therapy (IIAT) on in-hospital mortality of patients in the emergency department (ED) with Escherichia coli and Klebsiella pneumoniae BSIs. This retrospective single-center cohort study included all adult patients with E. coli and K. pneumoniae BSIs between January 2007 and December 2013, who had undergone a blood culture test and initiation of antibiotics within 6 h of ED registration time. Multiple logistic regression was used to adjust for bacterial species, IIAT, time to antibiotics, age, sex, quick Sepsis Related Organ Failure Assessment (qSOFA) score2, and comorbidities. A total of 3533 patients were enrolled (2967 alive and 566 deceased, in-hospital mortality rate 16%). The patients with K. pneumoniae ESBL-positive BSI had the highest mortality rate. Non-survivors had qSOFA scores2 (33.6% vs 9.5%, P<0.001), more IIAT (15.0% vs 10.7%, P=0.004), but shorter mean time to antibiotics (1.70 vs 1.84h, P<0.001). A qSOFA score2 is the most significant predictor for in-hospital mortality; however, IIAT and time to antibiotics were not significant predictors in multiple logistic regression analysis. In subgroup analysis divided by qSOFA scores, IIAT was still not a significant predictor. Severity of the disease (qSOFA score2) is the key factor influencing in-hospital mortality of patients with E. coli and K. pneumoniae BSIs. The time to antibiotics and IIAT were not significant predictors because they in turn were affected by disease severity. |
URI: | http://dx.doi.org/10.1177/2058738420942375 https://www.webofscience.com/wos/woscc/full-record/WOS:000615279800001 https://ir.csmu.edu.tw:8080/handle/310902500/24346 |
Relation: | INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY ,2020 ,v34 |
Appears in Collections: | [中山醫學大學研究成果] 期刊論文
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