Effect of Interval between Human Chorionic Gonadotropin Priming and Ovum Pick-up on the Euploid Probabilities of Blastocyst

doi:10.3390/jcm9061685

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24330

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24330

Title:	Effect of Interval between Human Chorionic Gonadotropin Priming and Ovum Pick-up on the Euploid Probabilities of Blastocyst
Authors:	Lee, CI;Chen, HH;Huang, CC;Chen, CH;Cheng, EH;Huang, JY;Lee, MS;Lee, TH
Keywords:	preimplantation genetic test;human chorionic gonadotropin priming;hCG-OPU interval;euploidy probability;blastocyst biopsy
Date:	2020
Issue Date:	2022-08-09T08:00:32Z (UTC)
Publisher:	MDPI
Abstract:	This retrospective study attempts to elucidate the relevance of the interval between human chorionic gonadotropin priming and oocyte pick-up (hCG-OPU) to the euploidy probability of biopsied blastocysts in preimplantation genetic tests for aneuploidy (PGT-A) cycles. A total of 1889 blastocysts from 511 patients undergoing PGT- A cycles were used. An analysis of generalized estimating equations (GEE) was used to identify whether the hCG-OPU interval is associated with euploidy probabilities of blastocysts. Accordingly, maternal age (OR: 0.925, 95% CI: 0.903-0.948,p< 0.001) and the hCG-OPU interval (OR: 1.138, 95% CI: 1.028-1.260,p= 0.013) were the two significant factors associated with the euploidy probabilities. The Cochran-Armitage trend test demonstrated that the blastocyst euploidy percentage increased progressively with the increasing hCG-OPU interval in normal responders (p= 0.006) and advanced maternal age (age >= 38 years;p= 0.020) groups. In normal responders, the euploidy rate was highest in the 38-39 h interval (43.1%, 47/109). In contrast, the euploidy rate was lowest in the 34-35 h interval (28.7%, 29/105). In conclusion, the present study demonstrated that at an hCG-OPU interval between 34-39 h, the longer the hCG-OPU interval, the higher the probability of euploidy for blastocysts.
URI:	http://dx.doi.org/10.3390/jcm9061685 https://www.webofscience.com/wos/woscc/full-record/WOS:000553589200001 https://ir.csmu.edu.tw:8080/handle/310902500/24330
Relation:	JOURNAL OF CLINICAL MEDICINE ,2020 ,v9 ,issue 6
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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