中山醫學大學機構典藏 CSMUIR:Item 310902500/24305
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    题名: The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death
    作者: Hsin, IL;Chou, YH;Hung, WL;Ko, JL;Wang, PH
    关键词: ABT-737;apoptosis;arsenic trioxide;autophagy;uterine cervical cancer
    日期: 2020
    上传时间: 2022-08-09T08:00:08Z (UTC)
    出版者: MDPI
    摘要: ABT-737, a B cell lymphoma-2 (Bcl-2) family inhibitor, activates apoptosis in cancer cells. Arsenic trioxide is an apoptosis activator that impairs cancer cell survival. The aim of this study was to evaluate the effect of a combination treatment with ABT-737 and arsenic trioxide on uterine cervical cancer cells. MTT (3-(4,5-dimethylthiazol-2-yl)-25-diphenyltetrazolium bromide) assay revealed that ABT-737 and arsenic trioxide induced a synergistic effect on uterine cervical cancer cells. Arsenic trioxide enhanced ABT-737-induced apoptosis and caspase-7 activation and the ABT-737-mediated reduction of anti-apoptotic protein Mcl-1 in Caski cells. Western blot assay revealed that arsenic trioxide promoted the ABT-737-mediated reduction of CDK6 and thymidylate synthetase in Caski cells. Arsenic trioxide promoted ABT-737-inhibited mitochondrial membrane potential and ABT-737-inhibited ANT expression in Caski cells. However, ABT-737-elicited reactive oxygen species were not enhanced by arsenic trioxide. The combined treatment induced an anti-apoptosis autophagy in SiHa cells. This study is the first to demonstrate that a combination treatment with ABT-737 and arsenic trioxide induces a synergistic effect on uterine cervical cancer cells through apoptosis. Our findings provide new insights into uterine cervical cancer treatment.
    URI: http://dx.doi.org/10.3390/cancers12010108
    https://www.webofscience.com/wos/woscc/full-record/WOS:000516826700108
    https://ir.csmu.edu.tw:8080/handle/310902500/24305
    關聯: CANCERS ,2020 ,v12 ,issue 1
    显示于类别:[中山醫學大學研究成果] 期刊論文

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