中山醫學大學機構典藏 CSMUIR:Item 310902500/24301
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    题名: Associations between Coenzyme Q10 Status, Oxidative Stress, and Muscle Strength and Endurance in Patients with Osteoarthritis
    作者: Chang, PS;Yen, CH;Huang, YY;Chiu, CJ;Lin, PT
    关键词: coenzyme Q10;oxidative stress;muscle mass;muscle function;osteoarthritis;aging
    日期: 2020
    上传时间: 2022-08-09T08:00:04Z (UTC)
    出版者: MDPI
    摘要: Osteoarthritis (OA) causes oxidative stress. Coenzyme Q10 is an antioxidant that participates in energy production in the human body. The purpose of this study was to investigate the relationships among coenzyme Q10 status, oxidative stress, antioxidant capacity, and muscle function in patients with OA. This case-control study recruited 100 patients with OA and 100 without OA. The coenzyme Q10 status, oxidative stress, antioxidant capacity, muscle mass (by dual-energy X-ray absorptiometry), muscle strength (hand-grip and leg-back strength), and muscle endurance (dumbbell curls, gait speed, chair-stand test, and short physical performance battery) were measured. The results showed that both OA and elderly subjects had a low coenzyme Q10 status (<0.5 mu M). Oxidative stress was significantly negatively correlated with muscle function (protein carbonyl, p < 0.05). Coenzyme Q10 level was positively associated with antioxidant capacity, muscle mass, muscle strength and muscle endurance in patients with OA (p < 0.05). Since OA is an age-related disease, coenzyme Q10 may be consumed by oxidative stress and thereby affect muscle function. Raising coenzyme Q10 in patients with OA could be suggested, which may benefit their antioxidant capacity and muscle function.
    URI: http://dx.doi.org/10.3390/antiox9121275
    https://www.webofscience.com/wos/woscc/full-record/WOS:000602243100001
    https://ir.csmu.edu.tw:8080/handle/310902500/24301
    關聯: ANTIOXIDANTS ,2020 ,v9 ,issue 12
    显示于类别:[中山醫學大學研究成果] 期刊論文

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