Associations between Coenzyme Q10 Status, Oxidative Stress, and Muscle Strength and Endurance in Patients with Osteoarthritis

doi:10.3390/antiox9121275

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24301

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24301

Title:	Associations between Coenzyme Q10 Status, Oxidative Stress, and Muscle Strength and Endurance in Patients with Osteoarthritis
Authors:	Chang, PS;Yen, CH;Huang, YY;Chiu, CJ;Lin, PT
Keywords:	coenzyme Q10;oxidative stress;muscle mass;muscle function;osteoarthritis;aging
Date:	2020
Issue Date:	2022-08-09T08:00:04Z (UTC)
Publisher:	MDPI
Abstract:	Osteoarthritis (OA) causes oxidative stress. Coenzyme Q10 is an antioxidant that participates in energy production in the human body. The purpose of this study was to investigate the relationships among coenzyme Q10 status, oxidative stress, antioxidant capacity, and muscle function in patients with OA. This case-control study recruited 100 patients with OA and 100 without OA. The coenzyme Q10 status, oxidative stress, antioxidant capacity, muscle mass (by dual-energy X-ray absorptiometry), muscle strength (hand-grip and leg-back strength), and muscle endurance (dumbbell curls, gait speed, chair-stand test, and short physical performance battery) were measured. The results showed that both OA and elderly subjects had a low coenzyme Q10 status (<0.5 mu M). Oxidative stress was significantly negatively correlated with muscle function (protein carbonyl, p < 0.05). Coenzyme Q10 level was positively associated with antioxidant capacity, muscle mass, muscle strength and muscle endurance in patients with OA (p < 0.05). Since OA is an age-related disease, coenzyme Q10 may be consumed by oxidative stress and thereby affect muscle function. Raising coenzyme Q10 in patients with OA could be suggested, which may benefit their antioxidant capacity and muscle function.
URI:	http://dx.doi.org/10.3390/antiox9121275 https://www.webofscience.com/wos/woscc/full-record/WOS:000602243100001 https://ir.csmu.edu.tw:8080/handle/310902500/24301
Relation:	ANTIOXIDANTS ,2020 ,v9 ,issue 12
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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