In vitro comparisons of microscale and nanoscale calcium silicate particles

doi:10.1039/d0tb01202e

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24284

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24284

Title:	In vitro comparisons of microscale and nanoscale calcium silicate particles
Authors:	Huang, YR;Wu, IT;Chen, CC;Ding, SJ
Date:	2020
Issue Date:	2022-08-09T07:59:46Z (UTC)
Publisher:	ROYAL SOC CHEMISTRY
ISSN:	2050-750X
Abstract:	Calcium silicate (CaSi) materials have been used for bone repair and generation due to their osteogenic properties. Tailoring the surface chemistry and structure of CaSi can enhance its clinical performance. There is no direct comparison between microscale and nanoscale CaSi particles. Therefore, this article aimed to compare and evaluate the surface chemistry, structure, and in vitro properties of microscale CaSi (mu CaSi) and nanoscale CaSi (nCaSi) particles synthesized by the sol-gel method and precipitation method, respectively. As a result, the semi-crystalline mu CaSi powders were assemblies of irregular microparticles containing a major beta-dicalcium silicate phase, while the amorphous nCaSi powders consisted of spherical particles with a size of 100 nm. After soaking in a Tris-HCl solution, the amount of Si ions released from nCaSi was higher than that released from mu CaSi, but there was no significant difference in Ca ion release between the two CaSi particles. Compared to microscale CaSi (mu CaSi), nanoscale CaSi (nCaSi) significantly enhanced the growth and differentiation of human mesenchymal stem cells (hMSC) and inhibited the function of RAW 264.7 macrophages. In the case of antibacterial activity against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus), nanoscale nCaSi displayed a higher bacteriostatic ratio, a greater growth inhibition zone and more reactive oxygen species (ROS) production than microscale mu CaSi. The conclusion is that nanoscale CaSi had greater antibacterial and osteogenic activity compared to microscale CaSi. Next generation CaSi-based materials with unique properties are emerging to meet specific clinical needs.
URI:	http://dx.doi.org/10.1039/d0tb01202e https://www.webofscience.com/wos/woscc/full-record/WOS:000550975200015 https://ir.csmu.edu.tw:8080/handle/310902500/24284
Relation:	JOURNAL OF MATERIALS CHEMISTRY B ,2020 ,v8 ,issue 28 ,p6034-6047
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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