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https://ir.csmu.edu.tw:8080/ir/handle/310902500/24272
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| Title: | REGULATION OF PROINFLAMMATORY ENZYMES BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA IN ASTROGLIA INFECTED WITH TOXOPLASMA GONDII |
| Authors: | Shyu, LY;Chen, KM;Lu, CY;Lai, SC |
| Keywords: | Astroglia;Proinflammatory Enzymes;Toxoplasma gondii |
| Date: | 2020 |
| Issue Date: | 2022-08-09T07:59:34Z (UTC)
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| Publisher: | ALLEN PRESS INC |
| ISSN: | 0022-3395 |
| Abstract: | Peroxisome proliferator-activated receptor gamma (PPAR gamma) regulates neuroinflammation, and its agonists act as neuroprotective agents. This study aims to investigate the correlation between PPAR gamma and proinflammatory enzyme expression in astroglia infected with Toxoplasma gondii tachyzoite in vitro. Our results showed that matrix metalloprotease (MMP)- 2, MMP-9, cyclooxygenase-2 (COX-2), prostaglandin (PGE)-2, inducible nitric-oxide synthase (iNOS), and nitric oxide (NO) were significantly increased in T. gondii-infected astroglia. Furthermore, the expression levels of MMP-2, MMP-9, COX-2, PGE-2, iNOS, and NO were significantly decreased by rosiglitazone-a PPAR gamma agonist. By contrast, the treatment with GW9662, a PPAR gamma antagonist, efficiently increased the expression levels of MMP-2, MMP-9, COX-2, PGE-2, iNOS, and NO. These results suggested that the treatment with rosiglitazone offers a potential strategy for controlling the inflammatory factors in T. gondii infection. |
| URI: | http://dx.doi.org/10.1645/18-184
https://www.webofscience.com/wos/woscc/full-record/WOS:000571479700004
https://ir.csmu.edu.tw:8080/handle/310902500/24272 |
| Relation: | JOURNAL OF PARASITOLOGY ,2020 ,v106 ,issue 5 ,p564-571 |
| Appears in Collections: | [中山醫學大學研究成果] 期刊論文
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